Evidence map›Paper›PMID 31916747›Full record

ArticleACS chemical neuroscience2020

Histamine Receptors Regulate the Activity, Surface Expression, and Phosphorylation of Serotonin Transporters.

Balasubramaniam Annamalai, Durairaj Ragu Varman, Rebecca E Horton, Lynette C Daws, Lankupalle D Jayanthi, Sammanda Ramamoorthy

Open access · greenAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
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  5. Review
  6. Article
  7. Inflammation-Induced Histamine Impairs the Capacity of Escitalopram to Increase Hippocampal Extracellular Serotonin.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Balasubramaniam AnnamalaiDepartment of Neurosciences , Medical University of South Carolina , Charleston , South Carolina 29425 , United States.
Durairaj Ragu VarmanDepartment of Pharmacology and Toxicology , Virginia Commonwealth University , Richmond , Virginia 23298 , United States.
Rebecca E HortonDepartment of Cellular and Integrative Physiology , University of Texas Health Science Center at San Antonio , San Antonio , Texas 78229 , United States.
Lynette C DawsDepartment of Cellular and Integrative Physiology , University of Texas Health Science Center at San Antonio , San Antonio , Texas 78229 , United States.
Lankupalle D JayanthiDepartment of Pharmacology and Toxicology , Virginia Commonwealth University , Richmond , Virginia 23298 , United States.
Sammanda RamamoorthyDepartment of Pharmacology and Toxicology , Virginia Commonwealth University , Richmond , Virginia 23298 , United States.ORCID 0000-0003-1093-7887
Virginia Commonwealth University · USThe University of Texas Health Science Center at San Antonio · USMedical University of South Carolina · US

Funding

Serotonin Transporter PhosphorylationR01MH062612 · NIMH · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAMAMOORTHY, SAMMANDA · 2002 to 2011
$2.4M
In Vivo Serotonin Transporter Dysregulation in Psychiatric DisordersR01MH112731 · NIMH · VIRGINIA COMMONWEALTH UNIVERSITY · PI RAMAMOORTHY, SAMMANDA · 2018 to 2020
$1.2M
NIMH NIH HHS R01 MH062612NIMH NIH HHS R01 MH112731
6 · The paper itself

Abstract

Reuptake and clearance of released serotonin (5-HT) are critical in serotonergic neurotransmission. Serotonin transporter (SERT) is mainly responsible for clearing the extracellular 5-HT. Controlled trafficking, phosphorylation, and protein stability have been attributed to robust SERT activity. H

Indexed as

AnimalsBiological TransportCorpus StriatumMaleRats, Sprague-DawleyReceptors, HistamineSerotoninSerotonin Plasma Membrane Transport ProteinsSynaptic TransmissionSynaptosomesReceptors, HistamineSerotoninSerotonin Plasma Membrane Transport ProteinsclearancedepolarizationHistaminehistamine H3 receptorserotoninserotonin transporter

Identifiers

PMID31916747
PMCPMC7004881
OpenAlexW2999286456

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.