ArticleHuman brain mapping2020
The buildup of an urge in obsessive-compulsive disorder: Behavioral and neuroimaging correlates.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- The relationship between sensory phenomena and interoception across the obsessive-compulsive spectrum: a systematic review.BMC psychiatry · 2025Pooled it
- A diffusion MRI-based structural assessment of the striatal compartments, striosome and matrix, in Obsessive Compulsive Disorder.Research square · 2026Article
- Parietal signatures of urge control in paediatric tic disorders: Hyperactivation and salience-biased coupling.European child & adolescent psychiatry · 2026Article
- Differences in response inhibition between medication-free patients with obsessive-compulsive disorder with and without sensory phenomena.Journal of neuropsychology · 2026Article
- Reliability and validity of the Chinese version of The University of São Paulo Sensory Phenomena Scale in OCD patients.BMC psychiatry · 2025Article
- Personalized non-invasive neuromodulation for sensory-based urge suppression in individuals with OCD: a proof-of-concept investigation.Frontiers in human neuroscience · 2025Article
- Uncovering the neural correlates of the urge-to-blink: A study utilising subjective urge ratings and paradigm free mapping.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Identifying subgroups of urge suppression in Obsessive-Compulsive Disorder using machine learning.Journal of psychiatric research · 2024Article
- Sensory over-responsivity and orbitofrontal cortex connectivity in obsessive-compulsive disorder.Journal of affective disorders · 2024Article
- The Seeking Proxies for Internal States (SPIS) Model of OCD - A Comprehensive Review of Current Findings and Implications for Future Directions.Current neuropharmacology · 2024Review
- Failures of Urge Suppression in Obsessive-Compulsive Disorder: Behavioral Modeling Using a Blink Suppression Task.Journal of obsessive-compulsive and related disorders · 2023Article
- Different degrees of nodes behind obsessive-compulsive symptoms of schizophrenia.Frontiers in psychiatry · 2023Article
- Relationships between interoceptive sensibility and resting-state functional connectivity of the insula in obsessive-compulsive disorder.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Toward a neurocircuit-based taxonomy to guide treatment of obsessive-compulsive disorder.Molecular psychiatry · 2021Review
- Interoception and Obsessive-Compulsive Disorder: A Review of Current Evidence and Future Directions.Frontiers in psychiatry · 2021Review
- The Emerging Science of Interoception: Sensing, Integrating, Interpreting, and Regulating Signals within the Self.Trends in neurosciences · 2021Review
- The buildup of an urge in obsessive-compulsive disorder: Behavioral and neuroimaging correlates.Human brain mapping · 2020Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Obsessive-compulsive disorder (OCD) is highly heterogeneous. While obsessions often involve fear of harm, many patients report uncomfortable sensations and/or urges that drive repetitive behaviors in the absence of a specific fear. Prior work suggests that urges in OCD may be similar to everyday "urges-for-action" (UFA) such as the urge to blink, swallow, or scratch, but very little work has investigated the pathophysiology underlying urges in OCD. In the current study, we used an urge-to-blink approach to model sensory-based urges that could be experimentally elicited and compared across patients and controls using the same task stimuli. OCD patients and controls suppressed eye blinking over a period of 60 s, alternating with free blinking blocks, while brain activity was measured using functional magnetic resonance imaging. OCD patients showed significantly increased activation in several regions during the early phase of eyeblink suppression (first 30 s), including mid-cingulate, insula, striatum, parietal cortex, and occipital cortex, with lingering group differences in parietal and occipital regions during late eyeblink suppression (last 30 s). There were no differences in brain activation during free blinking blocks, and no conditions where OCD patients showed reduced activation compared to controls. In an exploratory analysis of blink counts performed in a subset of subjects, OCD patients were less successful than controls in suppressing blinks. These data indicate that OCD patients exhibit altered brain function and behavior when experiencing and suppressing the urge to blink, raising the possibility that the disorder is associated with a general abnormality in the UFA system that could ultimately be targeted by future treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.