Evidence map›Paper›PMID 31916327›Full record

ArticleCell proliferation2020

Retinal blood vessel-origin yes-associated protein (YAP) governs astrocytic maturation via leukaemia inhibitory factor (LIF).

Li-Qian-Yu Ai, Rong-Di Yuan, Xi Chen, Yun-Jia Liu, Wen-Yi Liu, Jing-Yi Zhu, Zhou Zhang, Jun Yan, Chun-Lin Chen, Sen Lin and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell proliferation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Li-Qian-Yu AiDepartment of Ophthalmology, Research Institute of Surgery & Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, China.ORCID https://orcid.org/0000-0001-6433-6476
Rong-Di YuanDepartment of Ophthalmology, XinQiao Hospital, Army Medical University, Chongqing, China.
Xi ChenDepartment of Ophthalmology, Research Institute of Surgery & Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, China.
Yun-Jia LiuDepartment of Ophthalmology, Research Institute of Surgery & Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, China.
Wen-Yi LiuDepartment of Ophthalmology, Research Institute of Surgery & Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, China.
Jing-Yi ZhuDepartment of Ophthalmology, Research Institute of Surgery & Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, China.
Zhou ZhangDepartment of Ophthalmology, Research Institute of Surgery & Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, China.
Jun YanResearch Institute of Surgery & Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, China.
Chun-Lin ChenDepartment of Ophthalmology, Research Institute of Surgery & Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, China.
Sen LinDepartment of Ophthalmology, Research Institute of Surgery & Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, China.ORCID https://orcid.org/0000-0001-9346-8187
Jian YeDepartment of Ophthalmology, Research Institute of Surgery & Daping Hospital, Army Medical Center of PLA, Army Medical University, Chongqing, China.
Army Medical University · CN

Funding

Basic Research and Scientific Frontier Foundation of Chongqing cstc2019jcyj-msxmX0010National Natural Science Foundation of China 81371006National Natural Science Foundation of China 81570840Research Foundation of Dept. Ophthalmology in Daping Hospital, AMU 9-2543
6 · The paper itself

Abstract

objectivesTo testify that endothelial cells (ECs) induce astrocyte maturation by leukaemia inhibitory factor (LIF) secretion. MATERIALS AND

methodsIn vivo experiments, mice bearing floxed alleles of YAP were crossed with mice expressing a Cre recombinase driven by the endothelial Tek promoter (Tek-Cre) to finally obtain the following three genotypes: YAP

resultsIn vivo, YAP

conclusionsWe show that EC yes-associated protein (YAP) is not only a critical coactivator of Hippo signalling in retinal vessel development but also plays an essential role in retinal astrocyte maturation by regulating LIF production.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsAstrocytesCell DifferentiationCell ProliferationCoculture TechniquesEndothelial CellsFemaleGlial Fibrillary Acidic ProteinHumansLeukemia Inhibitory FactorMaleMiceMice, Inbred C57BLNeovascularization, PathologicNeovascularization, PhysiologicAdaptor Proteins, Signal TransducingGlial Fibrillary Acidic ProteinLeukemia Inhibitory FactorLIF protein, humanTranscription FactorsYAP1 protein, humanYAP-Signaling Proteinsastrocyte prematureleukaemia inhibitory factorretinal vessel developmentyes-associated protein

Identifiers

PMID31916327
PMCPMC7046482
OpenAlexW2999150822

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.