ArticleBritish journal of clinical pharmacology2020
One-year persistence of potentially inappropriate medication use in older adults: A population-based study.
Article in British journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Potentially Inappropriate Medication Use Among Older Adults with Cognitive Impairment and Dementia Attending Primary Care-Based Memory Clinics.Pharmacy (Basel, Switzerland) · 2025Article
- Trajectories of potentially inappropriate medication use among older adults in Saudi Arabia.Frontiers in pharmacology · 2025Article
- Potential inappropriate medications and drug-drug interactions in adverse drug reactions in the elderly: a retrospective study in a pharmacovigilance database.Frontiers in pharmacology · 2025Article
- Potentially inappropriate medication on communitydwelling older adults: Longitudinal analysis using the International Mobility in Aging Study.Biomedica : revista del Instituto Nacional de Salud · 2024Observational
- Sex-specific medication trajectories in older adults newly diagnosed with diabetes.Exploratory research in clinical and social pharmacy · 2023Article
- Risk factors for potentially inappropriate medication use in older adults: a cohort study.International journal of clinical pharmacy · 2022Article
- Low continuation of antipsychotic therapy in Parkinson disease - intolerance, ineffectiveness, or inertia?BMC neurology · 2021Article
- [Less can be more-Examples on medication in older and geriatric patients from current studies].Der Internist · 2021Review
- One-year persistence of potentially inappropriate medication use in older adults: A population-based study.British journal of clinical pharmacology · 2020Article
- Article
- Physician and patient-related factors associated with inappropriate prescribing to older patients within primary care: a cross-sectional study in Brazil.Sao Paulo medical journal = Revista paulista de medicinaArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
aimsTo assess the 1-year persistence of potentially inappropriate medication (PIM) use and identify associated factors in community-dwelling older adults in Quebec, Canada.
methodsA population-based cohort study was conducted using the Quebec Integrated Chronic Disease Surveillance System. Individuals insured by the public drug plan and aged ≥66 years who initiated a PIM between 1 April 2014 and 31 March 2015 were followed-up for 1 year. PIMs were identified using the 2015 Beers criteria. One-year persistence of PIM use was defined as continuous treatment with any PIM, without interruption for more than 60 days between prescriptions refills. Poisson regression models were performed to identify factors associated with 1-year persistence of any PIM.
resultsIn total, 25.1% of PIM initiators were persistent at 1 year. In non-persistent individuals, the median time to PIM discontinuation was 31 days (interquartile range 21-92). Individuals were more persistent at 1 year with antipsychotics (43.9%), long-duration sulphonylureas (40.2%), antiarrhythmics/immediate-release nifedipine (36.5%) and proton pump inhibitors (36.0%). Factors significantly associated with persistence were an increased age, being a man and having a high number of medications and chronic diseases, especially dementia, diabetes and cardiovascular diseases.
conclusionsOne-quarter of community-dwelling older adults are continuously exposed to PIMs. To optimize medication prescribing in the older population, further interventions are needed to limit the use of PIMs most likely to be continued, especially in individuals most at risk of being persistent and also particularly vulnerable to adverse events.
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