Evidence map›Paper›PMID 31916220›Full record

ReviewNeuromolecular medicine2020

A Review of Functional Electrical Stimulation Treatment in Spinal Cord Injury.

Shiyu Luo, Haonan Xu, Yi Zuo, Xiaogang Liu, Angelo H All

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Neuromolecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06796920 (Spinal Cord Stimulation Surgery for Improving Lower Limb Motor Dysfunction in Adrenomyeloneuropathy), which is not on this map. Cited by 47 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06796920 narecruitingnot on this mapstarted 2025, after this paper: background citation

Spinal Cord Stimulation Surgery for Improving Lower Limb Motor Dysfunction in Adrenomyeloneuropathy (AMN): A Prospective, Multicenter, Single-Arm, Self-Controlled Study.

TypeinterventionalSponsorThird Military Medical UniversityRan2025 to 2027Enrolled10ConditionsAdrenomyeloneuropathy Without Cerebral InvolvementArmsSpinal cord stimulation
3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Biomaterials and cell-based therapy post spinal cord injury.Journal of translational medicine · 2025
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Koopman-Based Model Predictive Control of Functional Electrical Stimulation for Ankle Dorsiflexion and Plantarflexion Assistance.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Shiyu LuoDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.
Haonan XuDepartment of Chemical & Biomolecular Engineering, Johns Hopkins University, Baltimore, MD, USA.
Yi ZuoDepartment of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD, USA.
Xiaogang LiuDepartment of Chemistry, National University of Singapore, Singapore, Singapore. chmlx@nus.edu.sg.
Angelo H AllDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA. hmn@jhu.edu.ORCID 0000-0002-7086-2170
Johns Hopkins University · USNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional electrical stimulation (FES) has been widely adopted to elicit muscle contraction in rehabilitation training after spinal cord injury (SCI). Conventional FES modalities include stimulations coupled with rowing, cycling, assisted walking and other derivatives. In this review, we studied thirteen clinical reports from the past 5 years and evaluated the effects of various FES aided rehabilitation plans on the functional recovery after SCI, highlighting upper and lower extremity strength, cardiopulmonary function, and balder control. We further explored potential mechanisms of FES using the Hebbian theory and lumbar locomotor central pattern generators. Overall, FES can be used to improve respiration, circulation, hand strength, mobility, and metabolism after SCI.

Indexed as

AnimalsCatsCentral Pattern GeneratorsCombined Modality TherapyElectric Stimulation TherapyExercise TestExercise TherapyGene Expression RegulationHumansMaleModels, NeurologicalMuscle FatigueMuscle Fibers, Fast-TwitchMuscle Fibers, Slow-TwitchMuscle, SkeletalNeurological RehabilitationFunctional electrical stimulationNeuroplasticityRehabilitationSpinal cord injury

Identifiers

PMID31916220
OpenAlexW2999645651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.