Evidence map›Paper›PMID 31916214›Full record

ReviewDiabetes therapy : research, treatment and education of diabetes and related disorders2020

Utility of Precision Medicine in the Management of Diabetes: Expert Opinion from an International Panel.

Sanjay Kalra, A K Das, Sarita Bajaj, Gagan Priya, Sujoy Ghosh, R N Mehrotra, Sambit Das, Parag Shah, Vaishali Deshmukh, Debmalya Sanyal and 18 more

Open access · goldAbstract readReview
In one paragraph

Review in Diabetes therapy : research, treatment and education of diabetes and related disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors at 20 institutions in 9 countries.

Sanjay KalraDepartment of Endocrinology, Bharti Hospital and BRIDE, Karnal, Haryana, India. brideknl@gmail.com.
A K DasDepartment of Endocrinology and Medicine, Pondicherry Institute of Medical Sciences, Puducherry, India.
Sarita BajajDepartment of Endocrinology, MLN Medical College, Allahabad, Uttar Pradesh, India.
Gagan PriyaDepartment of Endocrinology, Fortis Hospital, Chandigarh, Punjab, India.
Sujoy GhoshDepartment of Endocrinology and Metabolism, Institute of Post-Graduate Medical Education and Research (IPGMER), Kolkata, West Bengal, India.
R N MehrotraDepartment of Endocrinology, Apollo Hospitals, Jubilee Hills, Hyderabad, Telangana, India.
Sambit DasDepartment of Endocrinology, Apollo Hospitals, Bhubaneswar, Odisha, India.
Parag ShahDepartment of Endocrinology and Diabetes, Gujarat Endocrine Centre, Ahmedabad, Gujarat, India.
Vaishali DeshmukhDepartment of Endocrinology, Deshmukh Clinic and Research Centre, Pune, Maharashtra, India.
Debmalya SanyalDepartment of Endocrinology, KPC Medical College, Kolkata, West Bengal, India.
Sruti ChandrasekaranDepartment of Endocrinology and Diabetes, Dr Rela Institute of Medical Science (RIMC), Chennai, Tamil Nadu, India.
Deepak KhandelwalDepartment of Endocrinology and Diabetes, Maharaja Agrasen Hospital, New Delhi, India.
Amaya JoshiDepartment of Endocrinology and Diabetes, Bhaktivedanta Hospital and Research Institute, Mumbai, Maharashtra, India.
Tiny NairDepartment of Cardiology, PRS Hospital, Trivandrum, Kerala, India.
Fatimah ElianaDepartment of Internal Medicine, Faculty of Medicine, YARSI University, Jakarta, Indonesia.
Hikmat PermanaDepartment of Internal Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.
M D FariduddinDepartment of Endocrinology of Bangabandhu Sheikh, Mujib Medical University, Dhaka, Bangladesh.
Pradeep Krishna ShresthaDepartment of Internal Medicine, Tribhuwan University Teaching Hospital, Kathmandu, Nepal.
Dina ShresthaDepartment of Endocrinology, Norvic International Hospital, Kathmandu, Nepal.
Shayaminda KahandawaDepartment of Endocrinology, Teaching Hospital Karapitiya, Karapitiya, Galle, Sri Lanka.
Manilka SumanathilakaDepartment of Endocrinology, National Hospital of Sri Lanka, Colombo, Sri Lanka.
Ahamed ShaheedDepartment of Internal Medicine, Indira Gandhi Memorial Hospital, Malé, Republic of Maldives.
Aly Ahmed Abdel RahimDepartment of Diabetes and Metabolism, Alexandria University, Alexandria, Egypt.
Abbas OrabiDepartment of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Ahmed Al-AniDepartment of Internal Medicine, Hamad General Hospital, Doha, Qatar.
Wiam HusseinDepartment of Endocrinology and Diabetes, Royal Hospital, Manama, Bahrain.
Dinesh KumarDepartment of Endocrinology, NMC Specialty Hospital, Abu Dhabi, United Arab Emirates.
Khalid ShaikhDepartment of Diabetes, Faculty of Internal Medicine, Royal Oman Police Hospital, Muscat, Oman.
Alexandria University · EGApollo Hospitals · INApollo Hospitals · INBangabandhu Sheikh Mujib Medical University · BDBhaktivedanta Hospital & Research Institute · INBharti Hospital · INFortis Hospital · INGrande International Hospital · NPHamad General Hospital · QAIndira Gandhi Memorial Hospital · MVInstitute of Post Graduate Medical Education and Research · INKPC Medical College and Hospital · INMotilal Nehru Medical College · INNational Hospital of Sri Lanka · LKPadjadjaran University · IDParas Hospitals · INPondicherry Institute of Medical Sciences · INRoyal Hospital · OMTeaching Hospital Kandy · LKTribhuvan University Teaching Hospital · NP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe primary objective of this review is to develop a practice-based expert group opinion on the role of precision medicine with a specific focus on sulfonylureas (SUs) in diabetes management.

backgroundThe clinical etiology, presentation and complications of diabetes vary from one patient to another, making the management of the disease challenging. The pre-eminent feature of diabetes mellitus (DM) are chronically elevated blood glucose concentrations; however, in clinical practice, the exclusion of autoimmunity, pregnancy, pancreatic disease or injury and rare genetic forms of diabetes is crucial. Within this framework, precision medicine provides unique insights into the risk factors and natural history of DM. Precision medicine goes beyond genomics and encompasses patient-centered care, molecular technologies and data sharing. Precision medicine has evolved in the field of diabetology. It has helped improve the efficacy of SUs, a class of drugs, which have been effectively used in the management of diabetes mellitus for decades, and it has enabled the expansion of SUs use in diabetes patients with genetic mutations. REVIEW

resultsAfter due discussions, the expert group analyzed studies that focused on the use of SUs in diabetes patients with genomic variations and rare mutations. The expert group opined that SUs are important glucose-lowering drugs and that precision medicine helps in improving the efficacy of SUs by matching them to those patients who will benefit most.

conclusionPrecision medicine opens new vistas for the effective use of SUs in unexpected patient populations, such as those with genetic mutations.

Indexed as

Genetic polymorphismsMonogenic diabetesPrecision medicineSulfonylureas

Identifiers

PMID31916214
PMCPMC6995789
OpenAlexW2999383013

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.