Evidence map›Paper›PMID 31916126›Full record

ArticleAnnals of biomedical engineering2020

In Vivo Modulation of the Blood-Brain Barrier Permeability by Transcranial Direct Current Stimulation (tDCS).

Da Wi Shin, Jie Fan, Eric Luu, Wasem Khalid, Yifan Xia, Niranjan Khadka, Marom Bikson, Bingmei M Fu

2 registry-linked trialsOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07576517 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Perioperative Use of Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery: a 2×2 Factorial Trial

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2030Enrolled1,160ConditionsOlder Patients, Surgery, Dexmedetomidine, EsketamineArmsDex-Esk, Placebo, Active tDCS, Sham tDCS
NCT07576543 phase4not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Long-term Follow-up of Perioperative Dexmedetomidine-esketamine Combination and Transcranial Direct Current Stimulation for Prevention of Neurocognitive Complications in Older Patients After Non-cardiac Surgery

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2031Enrolled1,160ConditionsOlder Patients, Surgery, Dexmedetomidine, EsketamineArmsDex-Esk, Placebo, Active tDCS, Sham tDCS
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
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  7. Transport Across the Blood-Brain Barrier.Advances in experimental medicine and biology · 2026
    Review
  8. Tumor Metastasis in the Microcirculation.Advances in experimental medicine and biology · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Targeting Prefrontal Cortex Dysfunction in Pain.The Journal of pharmacology and experimental therapeutics · 2024
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Da Wi ShinDepartment of Biomedical Engineering, The City College of the City University of New York, 160 Convent Ave, New York, NY, 10031, USA.
Jie FanDepartment of Biomedical Engineering, The City College of the City University of New York, 160 Convent Ave, New York, NY, 10031, USA.
Eric LuuDepartment of Biomedical Engineering, The City College of the City University of New York, 160 Convent Ave, New York, NY, 10031, USA.
Wasem KhalidDepartment of Biomedical Engineering, The City College of the City University of New York, 160 Convent Ave, New York, NY, 10031, USA.
Yifan XiaDepartment of Biomedical Engineering, The City College of the City University of New York, 160 Convent Ave, New York, NY, 10031, USA.
Niranjan KhadkaDepartment of Biomedical Engineering, The City College of the City University of New York, 160 Convent Ave, New York, NY, 10031, USA.
Marom BiksonDepartment of Biomedical Engineering, The City College of the City University of New York, 160 Convent Ave, New York, NY, 10031, USA.
Bingmei M FuDepartment of Biomedical Engineering, The City College of the City University of New York, 160 Convent Ave, New York, NY, 10031, USA. fu@ccny.cuny.edu.ORCID http://orcid.org/0000-0001-9343-5895
City College of New York · US

Funding

The coupled vascular hypothesis for transcranial direct current stimulation (tDCS)R01NS101362 · NINDS · CITY COLLEGE OF NEW YORK · PI BIKSON, MAROM · 2017 to 2021
$1.7M
Tumor Cell Arrest and Adhesion in the MicrocirculationSC1CA153325 · NCI · CITY COLLEGE OF NEW YORK · PI FU, BINGMEI M. · 2010 to 2014
$750k
Modulation of blood-brain-barrier (BBB) permeability by tDCS relevant electric fiR21EB017510 · NIBIB · CITY COLLEGE OF NEW YORK · PI BIKSON, MAROM · 2014 to 2015
$421k
NCI NIH HHS SC1 CA153325NIBIB NIH HHS R21 EB017510NIH HHS R01 NS101362NIH HHS R21EB017510NIH HHS SC1CA153325NINDS NIH HHS R01 NS101362
6 · The paper itself

Abstract

tDCS has been used to treat various brain disorders and its mechanism of action (MoA) was found to be neuronal polarization. Since the blood-brain barrier (BBB) tightly regulates the neuronal microenvironment, we hypothesized that another MoA of tDCS is direct vascular activation by modulating the BBB structures to increase its permeability (P). To test this hypothesis, we used high resolution multiphoton microscopy to determine P of the cerebral microvessels in rat brain. We found that 20 min 0.1-1 mA tDCS transiently increases P to a small solute, sodium fluorescein (MW 376) and to a large solute, Dextran-70k, with a much higher increase in P to the large solute. By pretreating the vessel with a nitric oxide synthase inhibitor, we revealed that the tDCS-induced increase in P is NO dependent. A transport model for the BBB was further employed to predict the structural changes by the tDCS. Comparing model predictions with the measured data suggests that tDCS increases P by temporarily disrupting the structural components forming the paracellular pathway of the BBB. That the transient and reversible increase in the BBB permeability also suggests new applications of tDCS such as a non-invasive approach for brain drug delivery through the BBB.

Indexed as

Transcranial Direct Current StimulationAnimalsBlood-Brain BarrierDextransDrug Delivery SystemsFemaleFluoresceinNitric Oxide Synthaseomega-N-MethylargininePermeabilityRats, Sprague-DawleyDextransFluoresceinNitric Oxide Synthaseomega-N-MethylarginineMultiphoton microscopyNG-monomethyl-L-arginine (L-NMMA)Nitric oxide synthase (NOS) inhibitionNon-invasiveRatStructural mechanismsTransport model across the blood–brain barrier

Identifiers

PMID31916126
PMCPMC7096245
OpenAlexW2999068431

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.