Evidence map›Paper›PMID 31916094›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2020

Androgens Modulate Rat Granulosa Cell Steroidogenesis.

Manuel Doblado, Lingzhi Zhang, Tannaz Toloubeydokhti, Gabriel T Garzo, R Jeffrey Chang, Antoni J Duleba

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Manuel DobladoDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, 9500 Gilman Drive, 0633, La Jolla, San Diego, CA, 92093-0633, USA.
Lingzhi ZhangDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, 9500 Gilman Drive, 0633, La Jolla, San Diego, CA, 92093-0633, USA.
Tannaz ToloubeydokhtiDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, 9500 Gilman Drive, 0633, La Jolla, San Diego, CA, 92093-0633, USA.
Gabriel T GarzoReproductive Partners Fertility Center-San Diego, La Jolla, San Diego, CA, 92037, USA.
R Jeffrey ChangDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, 9500 Gilman Drive, 0633, La Jolla, San Diego, CA, 92093-0633, USA.
Antoni J DulebaDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Diego, 9500 Gilman Drive, 0633, La Jolla, San Diego, CA, 92093-0633, USA. aduleba@ucsd.edu.
University of California, San Diego · USSan Diego Fertility Center · US

Funding

The Role of FSH in Female InfertilityP50HD012303 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MELLON, PAMELA L · 1985 to 2020
$7.5M
TRAINING IN REPRODUCTIVE SCIENCEST32HD007203 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PAMELA L MELLON · 1988 to 2026
$4.8M
NICHD NIH HHS P50 HD012303NICHD NIH HHS T32 HD007203
6 · The paper itself

Abstract

Paracrine interactions between ovarian theca-interstitial cells (TICs) and granulosa cells (GCs) play an important role in the regulation of follicular steroidogenesis. Androgens serve as substrates for aromatization as well as affect GC function. This study evaluated the effects of co-culture of GC with TICs and the role of testosterone (T) and 5-alpha-dihydrotestosterone (DHT), and estradiol (E2) in modulation of GC expression of genes involved in the production of progesterone: 3β-hydroxysteroid dehydrogenase/Δ

Indexed as

AndrogensAnimalsCells, CulturedDihydrotestosteroneEstradiolFemaleGranulosa CellsRats, Sprague-DawleyRNA, MessengerTestosteroneTheca CellsAndrogensDihydrotestosteroneEstradiolRNA, MessengerTestosteroneAndrogensGene expressionGranulosa cellsRat

Identifiers

PMID31916094
PMCPMC7539820
OpenAlexW3000717984

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.