Evidence map›Paper›PMID 31915891›Full record

ReviewDiabetologia2020

Impact of circadian disruption on glucose metabolism: implications for type 2 diabetes.

Ivy C Mason, Jingyi Qian, Gail K Adler, Frank A J L Scheer

Registry-linked trialOpen access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05159141 (The Role of Circadian Rhythm in the Effect of Sleep Intervention on Obesity Prevention in Early Childhood), which is not on this map. Cited by 202 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
202citing papers in PubMed, 10 pooled it
16.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05159141 naunknown statusnot on this mapstarted 2022, after this paper: background citation

The Role of Circadian Rhythm in the Effect of Sleep Intervention on Obesity Prevention in Early Childhood

TypeinterventionalSponsorShanghai Jiao Tong University School of MedicineRan2022 to 2024Enrolled480ConditionsInfant Sleep ProblemArmsBehavioral sleep intervention
3 · Its place in the literature

Who cites it

202 citing papers in PubMed, 10 syntheses or guidelines pooled it, 338 citations in OpenAlex.

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  6. Social jetlag and obesity: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2024
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142 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ivy C MasonBrigham and Women's Hospital, Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, 221 Longwood Avenue, Boston, MA, 02115, USA.ORCID 0000-0003-4118-4275
Jingyi QianBrigham and Women's Hospital, Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, 221 Longwood Avenue, Boston, MA, 02115, USA.ORCID 0000-0002-8793-9330
Gail K AdlerDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3506-7347
Frank A J L ScheerBrigham and Women's Hospital, Medical Chronobiology Program, Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, 221 Longwood Avenue, Boston, MA, 02115, USA. fscheer@bwh.harvard.edu.ORCID 0000-0002-2014-7582
Brigham and Women's Hospital · US

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
TRAINING IN SLEEP, CIRCADIAN &RESPIRATORY NEUROBIOLOGYT32HL007901 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Charles A Czeisler · 1998 to 2026
$18.5M
TRAINING PROGRAM IN HYPERTENSIONT32HL007609 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ADLER, GAIL KURR · 1985 to 2022
$10.2M
Role of Meal Timing in Efficacy of Bariatric Surgery in Obese IndividualsR01HL140574 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A, TAVAKKOLI, ALI · 2017 to 2023
$4.2M
Melatonin and Receptor Gene Variant: Linking Circadian System and Type 2 DiabetesR01DK102696 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2015 to 2019
$3.8M
Impact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes RiskR01DK105072 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2016 to 2020
$3.2M
Meal Time Effects on Metabolic Health.R01DK099512 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2014 to 2017
$2.8M
Development of countermeasures against adverse metabolic effects of shift workR01HL118601 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SCHEER, FRANK A · 2014 to 2017
$2.6M
Aldosterone and Diabetic Cardiovascular Disease: Research and Mentoring ProgamK24HL103845 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI ADLER, GAIL KURR · 2011 to 2021
$1.6M
NCATS NIH HHS UL1 TR002541NHLBI NIH HHS K24 HL103845NHLBI NIH HHS R01 HL118601NHLBI NIH HHS R01 HL140574NHLBI NIH HHS T32 HL007609NHLBI NIH HHS T32 HL007901NIDDK NIH HHS R01 DK099512NIDDK NIH HHS R01 DK102696NIDDK NIH HHS R01 DK105072
6 · The paper itself

Abstract

The circadian system generates endogenous rhythms of approximately 24 h, the synchronisation of which are vital for healthy bodily function. The timing of many physiological processes, including glucose metabolism, are coordinated by the circadian system, and circadian disruptions that desynchronise or misalign these rhythms can result in adverse health outcomes. In this review, we cover the role of the circadian system and its disruption in glucose metabolism in healthy individuals and individuals with type 2 diabetes mellitus. We begin by defining circadian rhythms and circadian disruption and then we provide an overview of circadian regulation of glucose metabolism. We next discuss the impact of circadian disruptions on glucose control and type 2 diabetes. Given the concurrent high prevalence of type 2 diabetes and circadian disruption, understanding the mechanisms underlying the impact of circadian disruption on glucose metabolism may aid in improving glycaemic control.

Indexed as

AnimalsBlood GlucoseCarbohydrate MetabolismChronobiology DisordersCircadian RhythmDiabetes Mellitus, Type 2GlucoseHumansInsulin-Secreting CellsRisk FactorsSleepBlood GlucoseGlucoseBeta cell functionCircadian disruptionCircadian misalignmentCircadian rhythmDiabetesGlucose controlGlucose metabolismGlucose toleranceInsulin sensitivityReviewType 2 diabetes mellitus

Identifiers

PMID31915891
PMCPMC7002226
OpenAlexW3000654447

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.