Evidence map›Paper›PMID 31915706›Full record

ArticleBioMed research international2019

Analysis of Vascular Mechanical Characteristics after Coronary Degradable Stent Implantation.

Hao Ding, Ying Zhang, Yujia Liu, Chunxun Shi, Zhichao Nie, Haoyu Liu, Yuling Gu

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hao DingSchool of Medical Instrument, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.ORCID https://orcid.org/0000-0001-8456-8311
Ying ZhangSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Yujia LiuSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Chunxun ShiSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Zhichao NieSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Haoyu LiuSchool of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China.
Yuling GuResearch and Development Department, Shanghai Naturethink Life Science & Technology Co., Ltd., Shanghai 201809, China.
University of Shanghai for Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo explore the effect of vascular stress changes on endothelial function recovery and vascular restenosis inhibition, under the condition of dynamic degradation process of the degradable stent.

methodsFitting the material parameters of the hyperelastic vascular constitutive relationship, the stress distribution of the intima of the blood vessel before the stent was implanted and during the dynamic degradation was calculated by numerical simulation. In vitro culture experiments were carried out, and the stretch ratios of the silicone chamber were set to 0%, 5%, 10%, and 15%, respectively, to simulate the effects of different degradation stages on the growth state of endothelial cells.

resultsAfter the stent was completely degraded, the circumferential intimal stress (strain) of the vessel was recovered to 0.137 MPa, 5.5%, which was close to the physiological parameters (0.122 MPa, 4.8%) before stent implantation. In vitro experiments showed that the endothelial cell survival rate was the highest under the condition of circumferential stress (strain) of 0.1 MPa, 5%, and all adhesion growth could be achieved.

conclusionsWith the occurrence of degradation process of the stent, the circumferential stress (strain) of the intima was recovered to a range close to physiological parameters, which promotes the growth of endothelial cells. The recovery of intimal function can effectively inhibit the process of vascular restenosis. The results can provide a theoretical basis and experimental platform for the study of coronary intervention for the treatment of vascular restenosis.

Indexed as

Models, CardiovascularStentsBiomechanical PhenomenaCells, CulturedCell SurvivalCoronary VesselsHumansHuman Umbilical Vein Endothelial CellsTissue Culture Techniques

Identifiers

PMID31915706
PMCPMC6930720
OpenAlexW2991312913

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.