ArticlePeerJ2020
Survival between synchronous and non-synchronous multiple primary cutaneous melanomas-a SEER database analysis.
Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Multiple synchronous primary melanomas; A case report.JPRAS open · 2025Article
- Multiple Melanomas on Speckled Lentiginous Nevus: A Systematic Review and a Case Report.Journal of clinical medicine · 2025Review
- Synchronous occurrence of primary gastric and liver cancer: A case report.Oncology letters · 2025Article
- Effect of metachronous primary and secondary solid cancers in patients with multiple myeloma: a retrospective study from a single-center.Frontiers in immunology · 2025Article
- Article
- Synchronizing the Nomenclature Surrounding Synchronous Primary Cutaneous Melanomas: A Systematic Review.The Journal of clinical and aesthetic dermatology · 2024Review
- Successful delivery after in vitro fertilization-embryo transfer in a woman with metachronous primary cancer of ovary and endometrium: a case report.BMC pregnancy and childbirth · 2023Article
- Different situations of identifying second primary malignant tumors in lymphoma patients with synchronous solid tumors.Cancer medicine · 2023Article
- High incidence combination of multiple primary malignant tumors of the digestive system.World journal of gastroenterology · 2022Article
- Simultaneous multiple primary malignancies diagnosed by endoscopic ultrasound-guided fine-needle aspiration: A case report.World journal of clinical cases · 2022Article
- Case report: Lymph node metastases of breast cancer and thyroid cancer encountered in axilla.Frontiers in oncology · 2022Article
- Risks and cancer associations of metachronous and synchronous multiple primary cancers: a 25-year retrospective study.BMC cancer · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is no criterion to distinguish synchronous and non-synchronous multiple primary cutaneous melanomas (MPMs). This study aimed to distinguish synchronous and non-synchronous MPMs and compare the survivals of them using the Surveillance, Epidemiology, and End Results database.
methodsSynchronous and non-synchronous MPMs were distinguished by fitting the double log transformed distribution of the time interval between the first and second primary cutaneous melanomas (TIFtS) through a piecewise linear regression. The overall and melanoma-specific survivals were compared by the Kaplan-Meier method and Cox proportional hazard model through modeling the occurrence of synchronous MPMs as a time-dependent variable.
resultsThe distribution of TIFtS was composed by three power-law distributions. According to its first inflection point, synchronous MPMs were defined as tumors that occurred within 2 months. The Kaplain-Meier plot revealed a significant inferior survival for synchronous MPMs than non-synchronous MPMs (
conclusionsThis study provided data analysis evidences for using 2 months to distinguish synchronous MPMs and non-synchronous MPMs. Furthermore, the occurrence of synchronous MPM was a risk factor for prognosis of patients with CM.
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