ReviewOxidative medicine and cellular longevity2019
Autophagy: Multiple Mechanisms to Protect Skin from Ultraviolet Radiation-Driven Photoaging.
Review in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 95 citations in OpenAlex.
- Novel Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract provides potent skin benefits in vitro and protects skin from aging.Journal of cosmetic dermatology · 2024Trial
- Article
- The geroprotective potential of chalcones.Nature communications · 2025Review
- Amphibians as a source of bioactive antioxidant peptides: Emerging insights and therapeutic potential.Zoological research · 2025Review
- Screening of a Plant Extract Library from the Greek Flora for Biological Activities Related to Anti-Aging Applications.Antioxidants (Basel, Switzerland) · 2025Article
- Platelet-rich plasma alleviates skin photoaging by activating autophagy and inhibiting inflammasome formation.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Hydrogel-Based Therapies for Photoaging: Current Advances and Future Perspectives.Journal of cosmetic dermatology · 2025Review
- Autophagy-Enhancing Properties ofMolecules (Basel, Switzerland) · 2025Article
- Exploring Greek actinobacterial biodiversity for the discovery of bioactive metabolites with skin antiaging potential.Frontiers in microbiology · 2025Article
- Zinc Silicate-Loaded Microneedle Patch Reduces Reactive Oxygen Species Production and Enhances Collagen Synthesis for Ultraviolet B-Induced Skin Repair.Biomaterials research · 2025Article
- Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV.Frontiers in pharmacology · 2025Review
- P53 and the Ultraviolet Radiation-Induced Skin Response: Finding the Light in the Darkness of Triggered Carcinogenesis.Cancers · 2024Review
- Exploring the Potential of Anthocyanins for Repairing Photoaged Skin: A Comprehensive Review.Foods (Basel, Switzerland) · 2024Review
- The m6A writer KIAA1429 regulates photoaging progression via MFAP4-dependent collagen synthesis.BMC biology · 2024Article
- Antioxidants in Photoaging: From Molecular Insights to Clinical Applications.International journal of molecular sciences · 2024Review
- Aging in the dermis: Fibroblast senescence and its significance.Aging cell · 2024Review
- Marine Bioactive Peptides: Anti-Photoaging Mechanisms and Potential Skin Protective Effects.Current issues in molecular biology · 2024Review
- Exosomes in skin photoaging: biological functions and therapeutic opportunity.Cell communication and signaling : CCS · 2024Review
- Autophagy in Its (Proper) Context: Molecular Basis, Biological Relevance, Pharmacological Modulation, and Lifestyle Medicine.International journal of biological sciences · 2024Review
- Tanshinone Alleviates UVA-induced Melanogenesis in MelanocytesCurrent molecular medicine · 2024Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy is an essential cellular process that maintains balanced cell life. Restriction in autophagy may induce degenerative changes in humans. Natural or pathological aging of susceptible tissues has been linked with reduced autophagic activity. Skin photoaging is an example of such pathological condition caused by ambient solar UV radiation exposure. The UV-induced production of reaction oxygen species (ROS) has been linked to the promotion and progression of the photoaging process in exposed tissues. Accordingly, it has been suggested that autophagy is capable of delaying the skin photoaging process caused by solar ultraviolet (UV), although the underlying mechanism is still under debate. This review highlights several plausible mechanisms by which UV-induced ROS activates the cellular signaling pathways and modulates the autophagy. More specifically, the UV-mediated regulation of autophagy and age-related transcription factors is discussed to pinpoint the contribution of autophagy to antiphotoaging effects in the skin. The outcome of this review will provide insights into design intervention strategies for delaying the phenomenon of sunlight-induced photodamage, photoaging, and other aging-related chronic diseases based on factors that activate the autophagy process in the skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.