Evidence map›Paper›PMID 31915512›Full record

ArticleOxidative medicine and cellular longevity2019

Coenzyme Q10 Regulation of Apoptosis and Oxidative Stress in H

Xing Li, Jiheng Zhan, Yu Hou, Yonghui Hou, Shudong Chen, Dan Luo, Jiyao Luan, Le Wang, Dingkun Lin

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06452134 (Evaluation the Effect of Coenzyme Q10 on Tissue Healing Process in Patients Undergoing Wisdom Tooth Extraction in the City of Sanandaj-Iran in 1402), which is not on this map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06452134 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

Evaluation the Effect of Coenzyme Q10 on Tissue Healing Process in Patients Undergoing Wisdom Tooth Extraction in the City of Sanandaj-Iran in 1402: a Double-blinded Clinical Trial Study

TypeinterventionalSponsorZahra NejatiRan2024 to 2025Enrolled70ConditionsMolar, Third, Temporomandibular Joint Disorders, Dry Socket, Coenzyme Q10ArmsCoenzyme Q10 100 MG Oral Tablet, Placebo
3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 85 citations in OpenAlex.

  1. Trial
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  11. Article
  12. Article
  13. Ovarian aging: energy metabolism of oocytes.Journal of ovarian research · 2024
    Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Frontiers in veterinary science · 2024
    Article
  19. Article
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Xing LiDepartment of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong 510120, China.ORCID https://orcid.org/0000-0002-5676-8962
Jiheng ZhanDepartment of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong 510120, China.ORCID https://orcid.org/0000-0002-9370-3367
Yu HouDepartment of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong 510120, China.
Yonghui HouDepartment of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong 510120, China.ORCID https://orcid.org/0000-0002-2703-5292
Shudong ChenDepartment of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong 510120, China.
Dan LuoDepartment of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong 510120, China.ORCID https://orcid.org/0000-0003-1469-224X
Jiyao LuanDepartment of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong 510120, China.
Le WangDepartment of Spine Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.ORCID https://orcid.org/0000-0001-9633-7326
Dingkun LinDepartment of Orthopedic Surgery, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, No. 111 Dade Road, Guangzhou, Guangdong 510120, China.ORCID https://orcid.org/0000-0001-7153-6927
Guangzhou University of Chinese Medicine · CNSun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) has always been considered to be a devastating problem that results in catastrophic dysfunction, high disability rate, low mortality rate, and huge cost for the patient. Stem cell-based therapy, especially using bone marrow mesenchymal stem cells (BMSCs), is a promising strategy for the treatment of SCI. However, SCI results in low rates of cell survival and a poor microenvironment, which limits the therapeutic efficiency of BMSC transplantation. Coenzyme Q10 (CoQ10) is known as a powerful antioxidant, which inhibits lipid peroxidation and scavenges free radicals, and its combined effect with BMSC transplantation has been shown to have a powerful impact on protecting the vitality of cells, as well as antioxidant and antiapoptotic compounds in SCI. Therefore, we aimed to evaluate whether CoQ10 could decrease oxidative stress against the apoptosis of BMSCs

Indexed as

ApoptosisBone Marrow CellsMesenchymal Stem Cell TransplantationOxidative StressSpinal Cord InjuriesUbiquinoneAnimalsDisease Models, AnimalGA-Binding Protein Transcription FactorHydrogen PeroxideMaleMesenchymal Stem CellsNAD(P)H Dehydrogenase (Quinone)NF-E2-Related Factor 2RatsRats, Sprague-Dawleycoenzyme Q10GA-Binding Protein Transcription FactorGabpa protein, ratHydrogen PeroxideNAD(P)H Dehydrogenase (Quinone)NF-E2-Related Factor 2NQO1 protein, ratUbiquinone

Identifiers

PMID31915512
PMCPMC6930770
OpenAlexW2994914254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.