Evidence map›Paper›PMID 31915510›Full record

ReviewOxidative medicine and cellular longevity2019

The Use of Nutraceuticals to Counteract Atherosclerosis: The Role of the Notch Pathway.

Giorgio Aquila, Luisa Marracino, Valeria Martino, Donato Calabria, Gianluca Campo, Cristiana Caliceti, Paola Rizzo

Open access · hybridAbstract readReview
In one paragraph

Review in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 40 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Review
  5. Study Deciphering the Crucial Involvement of Notch Signaling Pathway in Human Cancers.Endocrine, metabolic & immune disorders drug targets · 2024
    Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Fermentation ofNutrients · 2022
    Article
  11. Article
  12. Novel Therapeutical Approaches to Managing Atherosclerotic Risk.International journal of molecular sciences · 2021
    Review
  13. Review
  14. Antiatherosclerosis Properties of Total Saponins of Garlic in Rats.Evidence-based complementary and alternative medicine : eCAM · 2020
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Giorgio AquilaDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.ORCID 0000-0002-3936-8895
Luisa MarracinoDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Valeria MartinoDepartment of Medical Sciences, University of Ferrara, Ferrara, Italy.
Donato CalabriaDepartment of Chemistry "Giacomo Ciamician, " Alma Mater Studiorum, University of Bologna, Via Selmi 2, 40126 Bologna, Italy.
Gianluca CampoCardiovascular Institute, Azienda Ospedaliero-Universitaria di Ferrara, Cona, Italy.ORCID 0000-0002-5150-188X
Cristiana CalicetiDepartment of Chemistry "Giacomo Ciamician, " Alma Mater Studiorum, University of Bologna, Via Selmi 2, 40126 Bologna, Italy.ORCID 0000-0002-6740-5331
Paola RizzoLaboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Ferrara, Italy.ORCID 0000-0001-7174-9674
University of Ferrara · ITUniversity of Bologna · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the currently available pharmacotherapies, today, thirty percent of worldwide deaths are due to cardiovascular diseases (CVDs), whose primary cause is atherosclerosis, an inflammatory disorder characterized by the buildup of lipid deposits on the inside of arteries. Multiple cellular signaling pathways have been shown to be involved in the processes underlying atherosclerosis, and evidence has been accumulating for the crucial role of Notch receptors in regulating the functions of the diverse cell types involved in atherosclerosis onset and progression. Several classes of nutraceuticals have potential benefits for the prevention and treatment of atherosclerosis and CVDs, some of which could in part be due to their ability to modulate the Notch pathway. In this review, we summarize the current state of knowledge on the role of Notch in vascular health and its modulation by nutraceuticals for the prevention of atherosclerosis and/or treatment of related CVDs.

Indexed as

AtherosclerosisDietary SupplementsHumansReceptors, NotchSignal TransductionReceptors, Notch

Identifiers

PMID31915510
PMCPMC6935452
OpenAlexW2943317578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.