Evidence map›Paper›PMID 31915410›Full record

ArticleProgress in polymer science2018

Biopolymer nanofibrils: structure, modeling, preparation, and applications.

Shengjie Ling, Wenshuai Chen, Yimin Fan, Ke Zheng, Kai Jin, Haipeng Yu, Markus J Buehler, David L Kaplan

Abstract read
In one paragraph

Article in Progress in polymer science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Manipulating the Assembly and Architecture of Fibrillar Silk.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Biomimetic Silk Architectures Outperform Animal Horns in Strength and Toughness.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shengjie LingSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Wenshuai ChenKey Laboratory of Bio-based Material Science & Technology, Ministry of Education, Northeast Forestry University, Harbin, China.
Yimin FanCollege of Chemical Engineering, Nanjing Forestry University, Nanjing, China.
Ke ZhengSchool of Physical Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
Kai JinDepartment of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Haipeng YuKey Laboratory of Bio-based Material Science & Technology, Ministry of Education, Northeast Forestry University, Harbin, China.
Markus J BuehlerDepartment of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
David L KaplanDepartment of Biomedical Engineering, Tufts University, Medford, MA, 02155, USA.

Funding

Translational Bioreactors - Engineering Complex TissuesP41EB002520 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2004 to 2018
$16.7M
Models to Predict Protein Biomaterial PerformanceU01EB014976 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI BUEHLER, MARKUS J., KAPLAN, DAVID L. · 2012 to 2020
$5.2M
Degradable orthopedic hardwareR01AR068048 · NIAMS · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L., LIN, SAMUEL J · 2015 to 2020
$2.0M
Focal Sustained Release Chemotherapy-Loaded Biomaterials at Tumor SitesR01NS094218 · NINDS · TUFTS UNIVERSITY MEDFORD · PI CHIU, BILL, KAPLAN, DAVID L. · 2017 to 2021
$1.7M
Injectable Gels for Tissue AugmentationR01EB021264 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI HOUSE, MICHAEL DOUGLAS, KAPLAN, DAVID L. · 2016 to 2019
$1.4M
NIAMS NIH HHS R01 AR068048NIBIB NIH HHS P41 EB002520NIBIB NIH HHS R01 EB021264NIBIB NIH HHS U01 EB014976NINDS NIH HHS R01 NS094218
6 · The paper itself

Abstract

Biopolymer nanofibrils exhibit exceptional mechanical properties with a unique combination of strength and toughness, while also presenting biological functions that interact with the surrounding environment. These features of biopolymer nanofibrils profit from their hierarchical structures that spun angstrom to hundreds of nanometer scales. To maintain these unique structural features and to directly utilize these natural supramolecular assemblies, a variety of new methods have been developed to produce biopolymer nanofibrils. In particular, cellulose nanofibrils (CNFs), chitin nanofibrils (ChNFs), silk nanofibrils (SNFs) and collagen nanofibrils (CoNFs), as the four most abundant biopolymer nanofibrils on earth, have been the focus of research in recent years due to their renewable features, wide availability, low-cost, biocompatibility, and biodegradability. A series of top-down and bottom-up strategies have been accessed to exfoliate and regenerate these nanofibrils for versatile advanced applications. In this review, we first summarize the structures of biopolymer nanofibrils in nature and outline their related computational models with the aim of disclosing fundamental structure-property relationships in biological materials. Then, we discuss the underlying methods used for the preparation of CNFs, ChNFs, SNF and CoNFs, and discuss emerging applications for these biopolymer nanofibrils.

Indexed as

biopolymerscellulosechitincollagennanofibrilssilk

Identifiers

PMID31915410
PMCPMC6948189

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.