Evidence map›Paper›PMID 31915378›Full record

ArticleNature2020

Microbiota-targeted maternal antibodies protect neonates from enteric infection.

Wen Zheng, Wenjing Zhao, Meng Wu, Xinyang Song, Florence Caro, Ximei Sun, Francesca Gazzaniga, Giuseppe Stefanetti, Sungwhan Oh, John J Mekalanos and 1 more

Open access · greenAbstract read
In one paragraph

Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 2 pooled it
18.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 2 syntheses or guidelines pooled it, 146 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Immune development in early life.Nature immunology · 2026
    Review
  7. Article
  8. Article
  9. FcγRIIB functions as an IgG transporter in the mammary gland.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Article
  11. Rethinking neonatalFrontiers in immunology · 2026
    Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Recent advances in antibody optimization based on deep learning methods.Journal of Zhejiang University. Science. B · 2025
    Review
  18. Article
  19. Article
  20. Review

33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 3 countries.

Wen Zheng *Department of Immunology, Harvard Medical School, Boston, MA, USA.
Wenjing Zhao *Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, School of Medicine, Sun Yat-sen University, Guangzhou, China.
Meng WuDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Xinyang SongDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Florence CaroDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Ximei SunDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Francesca GazzanigaDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Giuseppe StefanettiDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
Sungwhan OhDepartment of Immunology, Harvard Medical School, Boston, MA, USA.
John J MekalanosDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Dennis L KasperDepartment of Immunology, Harvard Medical School, Boston, MA, USA. dennis_kasper@hms.harvard.edu.
Harvard University · USSixth Affiliated Hospital of Sun Yat-sen University · CN

Funding

Targeting bacterial cell wall biogenesis for the development of novel antimicrobU19AI109764 · NIAID · HARVARD MEDICAL SCHOOL · PI KASPER, DENNIS L. · 2014 to 2018
$25.2M
Genetic analysis of toxinogenesis of Vibrio choleraeR37AI018045 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI John Joseph Mekalanos · 1989 to 2026
$12.8M
Genetic Analysis of Toxinogenesis in Vibrio CholeraeR01AI018045 · NIAID · HARVARD MEDICAL SCHOOL · PI MEKALANOS, JOHN JOSEPH · 2009 to 2018
$6.7M
Knowledge-based Vaccines Built on Paradigm Changes in Antigen PresentationR01AI089915 · NIAID · HARVARD MEDICAL SCHOOL · PI KASPER, DENNIS L. · 2011 to 2015
$2.1M
NKT Cell Mediated Immunoregulation by Symbiotic Gut Microbial GlycosphingolipidsK01DK102771 · NIDDK · HARVARD MEDICAL SCHOOL · PI OH, SUNGWHAN F · 2015 to 2019
$734k
NIAID NIH HHS 1U19 AI109764NIAID NIH HHS R01 AI018045NIAID NIH HHS R01 AI089915NIAID NIH HHS R37 AI018045NIAID NIH HHS U19 AI109764NIDDK NIH HHS K01 DK102771
6 · The paper itself

Abstract

Although maternal antibodies protect newborn babies from infection

Indexed as

AnimalsAntibodiesBreast FeedingCross ReactionsEnterotoxigenic Escherichia coliEscherichia coli InfectionsFemaleHumansImmunity, Maternally-AcquiredImmunoglobulin GInfant, NewbornMaleMiceMicrobiotaMilk, HumanMothersAntibodiesImmunoglobulin GReceptors, Fc

Identifiers

PMID31915378
PMCPMC7362890
OpenAlexW3000478494

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.