Evidence map›Paper›PMID 31915368›Full record

ReviewExperimental & molecular medicine2020

Apoptotic cell-derived exosomes: messages from dying cells.

Ramesh Kakarla, Jaehark Hur, Yeon Ji Kim, Jaeyoung Kim, Yong-Joon Chwae

Abstract readReview
In one paragraph

Review in Experimental & molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 218 papers.

0numbers the graph read from it
0cells of the map it votes in
218citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

218 citing papers in PubMed.

  1. Mast cell-derived extracellular vesicles in lung diseases: roles in pulmonary inflammation, immune regulation, and microenvironmental remodeling.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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158 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ramesh Kakarla *Department of Microbiology, Ajou University School of Medicine, Suwon, Gyeonggi-do, 16499, South Korea.
Jaehark Hur *Department of Microbiology, Ajou University School of Medicine, Suwon, Gyeonggi-do, 16499, South Korea.
Yeon Ji KimDepartment of Microbiology, Ajou University School of Medicine, Suwon, Gyeonggi-do, 16499, South Korea.
Jaeyoung KimCK-Exogene Inc, Seoul, 54853, South Korea.
Yong-Joon ChwaeDepartment of Microbiology, Ajou University School of Medicine, Suwon, Gyeonggi-do, 16499, South Korea. soiloie0603@hanmail.net.

Funding

Korea Health Industry Development Institute (KHIDI) HI16C0992National Research Foundation of Korea (NRF) NRF-2016R1D1A1B03934488National Research Foundation of Korea (NRF) NRF-2017R1D1A1B03034312National Research Foundation of Korea (NRF) NRF-2018R1D1A1B07048257
6 · The paper itself

Abstract

Apoptosis, a type of programmed cell death that plays a key role in both healthy and pathological conditions, releases extracellular vesicles such as apoptotic bodies and microvesicles, but exosome release due to apoptosis is not yet commonly accepted. Here, the reports demonstrating the presence of apoptotic exosomes and their roles in inflammation and immune responses are summarized, together with a general summary of apoptosis and extracellular vesicles. In conclusion, apoptosis is not just a 'silent' type of cell death but an active form of communication from dying cells to live cells through exosomes.

Indexed as

AnimalsApoptosisCell DeathCell-Derived MicroparticlesExosomesExtracellular VesiclesHumans

Identifiers

PMID31915368
PMCPMC7000698

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.