Evidence map›Paper›PMID 31915298›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Designing cyclic competence-stimulating peptide (CSP) analogs with pan-group quorum-sensing inhibition activity in

Yifang Yang, Jingjun Lin, Anthony Harrington, Gabriel Cornilescu, Gee W Lau, Yftah Tal-Gan

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 43 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
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  6. Article
  7. Competence Regulation inCurrent medicinal chemistry · 2025
    Review
  8. Streamlining marker-less allelic replacement inApplied and environmental microbiology · 2024
    Article
  9. Article
  10. Article
  11. The quorum-sensing peptidic inhibitor rescues host immune system eradication: A novel infectivity mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Attenuating theJournal of medicinal chemistry · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yifang YangDepartment of Chemistry, University of Nevada, Reno, Reno, NV 89557.
Jingjun LinDepartment of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802.
Anthony HarringtonDepartment of Chemistry, University of Nevada, Reno, Reno, NV 89557.
Gabriel CornilescuNational Magnetic Resonance Facility at Madison, University of Wisconsin-Madison, Madison, WI 53706.
Gee W LauDepartment of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, IL 61802; geelau@illinois.edu ytalgan@unr.edu.ORCID 0000-0002-7962-3950
Yftah Tal-GanDepartment of Chemistry, University of Nevada, Reno, Reno, NV 89557; geelau@illinois.edu ytalgan@unr.edu.ORCID 0000-0003-2052-6782
University of Nevada, Reno · USUniversity of Illinois Urbana-Champaign · USUniversity of Wisconsin–Madison · US

Funding

TR&D 3: TECHNOLOGY DEVELOPMENT FOR NMR STUDIES OF SMALL MOLECULES (METABOLOMICS, NATURAL PRODUCTS, METABOLITE-PROTEIN INTERACTIONS) pp.537-585 P41GM103399 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2012 to 2019
$9.4M
900 MHz NMR Spectrometer Biomolecular InvestigationsP41GM066326 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN L · 2002 to 2006
$5.0M
Controlling bactermic pneumococcal pneumonia with synthetic dominant-negative competence peptidesR01HL142626 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI LAU, GEE W, TALGAN, YIFTAH · 2019 to 2022
$2.0M
Chemical Biology Approaches to Investigate Cell-Signaling and Competition in Complex Bacterial CommunitiesR35GM128651 · NIGMS · UNIVERSITY OF NEVADA RENO · PI TALGAN, YIFTAH · 2018 to 2022
$1.9M
Mechanisms of Pseudomonas Resistance to Membrane Permeabilization by SP-AR01HL090699 · NHLBI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI LAU, GEE W · 2009 to 2012
$1.6M
WIDE-BORE 9.4 TESLA NMR SPECTROMETER FOR UW-MADISONS10RR002781 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI MARKLEY, JOHN L · 1986 to 1986
–
CONSOLE UPGRADES FOR NMR FACILITYS10RR008438 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI MARKLEY, JOHN L · 1993 to 1993
–
NCRR NIH HHS S10 RR002781NCRR NIH HHS S10 RR008438NHLBI NIH HHS R01 HL090699NHLBI NIH HHS R01 HL142626NIGMS NIH HHS P41 GM066326NIGMS NIH HHS P41 GM103399NIGMS NIH HHS R35 GM128651
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Amino Acid SequenceAnimalsBacterial ProteinsDisease Models, AnimalFemaleMaleMicePneumococcal InfectionsProtein BindingQuorum SensingRegulonStreptococcus pneumoniaeBacterial Proteinscompetence factor, Streptococcuscompetence-stimulating peptidecyclic peptidesquorum sensingStreptococcus pneumoniae

Identifiers

PMID31915298
PMCPMC6983377
OpenAlexW2999928323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.