ArticleProceedings of the National Academy of Sciences of the United States of America2020
Bioderivatization as a concept for renewable production of chemicals that are toxic or poorly soluble in the liquid phase.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 33 citations in OpenAlex.
- Metabolic engineering ofBiodesign research · 2025Article
- A synthetic metabolic pathway for the de novo biosynthesis of medium chain length γ- and δ-lactones.Journal of biological engineering · 2025Article
- Review
- A tandem conversion process for the synthesis of polyitaconic acid from glucose in the Aspergillus terreus culture.Bioprocess and biosystems engineering · 2025Article
- Computational-guided discovery of UDP-glycosyltransferases for lauryl glucoside production using engineered E. coli.Bioresources and bioprocessing · 2024Article
- An optogenetic toolkit for light-inducible antibiotic resistance.Nature communications · 2023Article
- Production of Fatty Acids and Derivatives Using Cyanobacteria.Advances in biochemical engineering/biotechnology · 2023Article
- The effects of different thermal and chemical stresses on release of outer membrane vesicles (OMVs) by ClearColi™.Archives of microbiology · 2022Article
- Alternative metabolic pathways and strategies to high-titre terpenoid production inNatural product reports · 2022Review
- Removal of Toxic Volatile Compounds in Batch Culture Prolongs Stationary Phase and Delays Death of Escherichia coli.Applied and environmental microbiology · 2021Article
- Production of 1-octanol in Escherichia coli by a high flux thioesterase route.Metabolic engineering · 2020Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bio-based production technologies may complement or replace petroleum-based production of chemicals, but they face a number of technical challenges, including product toxicity and/or water insolubility. Plants and microorganisms naturally biosynthesize chemicals that often are converted into derivatives with reduced toxicity or enhanced solubility. Inspired by this principle, we propose a bioderivatization strategy for biotechnological chemicals production, defined as purposeful biochemical derivatization of intended target molecules. As proof of principle, the effects of hydrophobic (e.g., esterification) and hydrophilic (e.g., glycosylation) bioderivatization strategies on the biosynthesis of a relatively toxic and poorly soluble chemical, 1-octanol, were evaluated in
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