Evidence map›Paper›PMID 31915261›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

Osteoclasts Derive Predominantly from Bone Marrow-Resident CX

Sanja Novak, Emilie Roeder, Judith Kalinowski, Sandra Jastrzebski, Hector L Aguila, Sun-Kyeong Lee, Ivo Kalajzic, Joseph A Lorenzo

Open access · greenAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Review
  3. Developmental Pathways of Immature CD11cInternational journal of molecular sciences · 2026
    Review
  4. Review
  5. An in vivo assay for osteoclast activity using mouse calvaria.Animal models and experimental medicine · 2026
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. The miR-29-3p family suppresses inflammatory osteolysis.Journal of cellular physiology · 2024
    Article
  11. Origin of Osteoclasts: Osteoclast Precursor Cells.Journal of bone metabolism · 2023
    Article
  12. Review
  13. Article
  14. Review
  15. Osteoclast biology in the single-cell era.Inflammation and regeneration · 2022
    Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Sanja NovakDepartment of Reconstructive Sciences, UConn Health, Farmington, CT 06030.ORCID 0000-0002-8042-932X
Emilie RoederDepartment of Reconstructive Sciences, UConn Health, Farmington, CT 06030.
Judith KalinowskiDepartment of Medicine, UConn Health, Farmington, CT 06030.
Sandra JastrzebskiDepartment of Medicine, UConn Health, Farmington, CT 06030.
Hector L AguilaDepartment of Immunology, UConn Health, Farmington, CT 06030.
Sun-Kyeong LeeUniversity of Connecticut Center on Aging, UConn Health, Farmington, CT 06030; and.ORCID 0000-0003-2276-6528
Ivo KalajzicDepartment of Reconstructive Sciences, UConn Health, Farmington, CT 06030.
Joseph A LorenzoDepartment of Medicine, UConn Health, Farmington, CT 06030; jlorenzo@uchc.edu.
UConn Health · US

Funding

Notch Signaling and Bone Fracture HealingR01AR055607 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI Kurt David Hankenson, IVO Kalajzic · 2011 to 2026
$6.3M
STUDIES ON THE REGULATION OF OSTEOCLAST PRECURSOR CELLSR01AR048714 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LORENZO, JOSEPH A · 2002 to 2011
$2.3M
Runx1 Control of Bone Resorption during Fracture Repair SupplementR01AR063661 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI DRISSI, MOULAY HICHAM, LORENZO, JOSEPH A · 2013 to 2017
$1.8M
Growth Factor Based on Enhancement of Bone RepairR01AR070813 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI KALAJZIC, IVO · 2017 to 2021
$1.7M
Studies of Osteoclast Lineage in Health and DiseaseR56AR074391 · NIAMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI LORENZO, JOSEPH A · 2019 to 2019
$412k
NIAMS NIH HHS R01 AR048714NIAMS NIH HHS R01 AR055607NIAMS NIH HHS R01 AR063661NIAMS NIH HHS R01 AR070813NIAMS NIH HHS R56 AR074391
6 · The paper itself

Abstract

Osteoclasts (OC) originate from either bone marrow (BM)-resident or circulating myeloid OC progenitors (OCP) expressing the receptor CX

Identifiers

PMID31915261
PMCPMC7002248
OpenAlexW2999400492

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.