Evidence map›Paper›PMID 31915250›Full record

ArticleThe Journal of biological chemistry2020

First characterization of glucose flux through the hexosamine biosynthesis pathway (HBP) in

Aaron K Olson, Bertrand Bouchard, Wei Zhong Zhu, John C Chatham, Christine Des Rosiers

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
5.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 76 citations in OpenAlex.

  1. Review
  2. Glucosamine as a regulator of O-GlcNAc signaling: linking metabolism to disease pathogenesis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Preventive nutrition and food science · 2024
    Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Metabolite signaling in the heart.Nature cardiovascular research · 2023
    Review
  17. Review
  18. Article
  19. The role of O-GlcNAcylation in development.Development (Cambridge, England) · 2023
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Aaron K OlsonDivision of Cardiology, Department of Pediatrics, University of Washington, Seattle, Washington 98105; Seattle Children's Research Institute, Seattle, Washington 98101. Electronic address: Aaron.Olson@seattlechildrens.org.
Bertrand BouchardMontreal Heart Institute Research Center and Department of Nutrition, Université de Montréal, Montreal, Québec H1T 1C8, Canada.
Wei Zhong ZhuSeattle Children's Research Institute, Seattle, Washington 98101.
John C ChathamDivision of Molecular and Cellular Pathology, Department of Pathology, University of Alabama, Birmingham, Alabama 35294.
Christine Des RosiersMontreal Heart Institute Research Center and Department of Nutrition, Université de Montréal, Montreal, Québec H1T 1C8, Canada.
Montreal Heart Institute · CACenter for Infectious Disease Research · USUniversity of Alabama at Birmingham · US

Funding

Metabolic regulation of O-GlcNAc and cardiac function during hypertrophyR01HL122546 · NHLBI · SEATTLE CHILDREN'S HOSPITAL · PI OLSON, AARON K · 2015 to 2019
$2.7M
NHLBI NIH HHS R01 HL122546
6 · The paper itself

Abstract

The hexosamine biosynthesis pathway (HBP) branches from glycolysis and forms UDP-GlcNAc, the moiety for

Indexed as

AcetylglucosamineAnimalsBiosynthetic PathwaysGlucoseGlycolysisGlycosylationHeartHexosaminesHumansMiceMyocardiumProtein Processing, Post-TranslationalAcetylglucosamineGlucoseHexosaminescarbohydrate metabolismcardiac metabolismglucosamineglucoseglucose metabolismhexosamine biosynthesis pathwaymetabolic fluxO-linked N-acetylglucosamine (O-GlcNAc)post-translational modification (PTM)protein glycosylationUDP-GlcNAc

Identifiers

PMID31915250
PMCPMC7029105
OpenAlexW2998898616

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.