Evidence map›Paper›PMID 31915219›Full record

ArticlemSphere2020

Manganese Uptake, Mediated by SloABC and MntH, Is Essential for the Fitness of Streptococcus mutans.

Jessica K Kajfasz, Callahan Katrak, Tridib Ganguly, Jonathan Vargas, Logan Wright, Zachary T Peters, Grace A Spatafora, Jacqueline Abranches, José A Lemos

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 60 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Genomic instability and biofilm determinants inbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Metal uptake systems underpinInfection and immunity · 2026
    Article
  7. Article
  8. Review
  9. SloR-SRE binding to theJournal of bacteriology · 2025
    Article
  10. E-Cigarette effects on oral health: A molecular perspective.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2025
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Small regulatory RNAs are mediators of theJournal of bacteriology · 2023
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Jessica K KajfaszDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA.
Callahan KatrakDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA.
Tridib GangulyDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA.
Jonathan VargasDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA.
Logan WrightDepartment of Biology, Middlebury College, Middlebury, Vermont, USA.
Zachary T PetersDepartment of Biology, Middlebury College, Middlebury, Vermont, USA.
Grace A SpataforaDepartment of Biology, Middlebury College, Middlebury, Vermont, USA.
Jacqueline AbranchesDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA jabranches@dental.ufl.edu jlemos@dental.ufl.edu.
José A LemosDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, Florida, USA jabranches@dental.ufl.edu jlemos@dental.ufl.edu.
University of Florida · USMiddlebury College · USFlorida College · US

Funding

Comprehensive Training Program in Oral BiologyT90DE021990 · NIDCR · UNIVERSITY OF FLORIDA · PI Jose A Lemos · 2011 to 2026
$8.2M
Investigating SloR virulence gene metalloregulation in Streptococcus mutansR01DE014711 · NIDCR · MIDDLEBURY COLLEGE · PI SPATAFORA, GRACE A. · 2004 to 2021
$4.1M
Role of the Spx Regulator in Streptococcus mutansR01DE019783 · NIDCR · UNIVERSITY OF ROCHESTER · PI LEMOS, JOSE A · 2010 to 2020
$3.7M
Significance of metal homeostasis to bacterial pathogenesis in chronic woundsR21AI137446 · NIAID · UNIVERSITY OF FLORIDA · PI LEMOS, JOSE A, WALLET, SHANNON MARGARET · 2018 to 2019
$419k
Investigating SloR virulence gene metalloregulation in S. mutans.R56DE014711 · NIDCR · MIDDLEBURY COLLEGE · PI SPATAFORA, GRACE A. · 2009 to 2009
$341k
NIAID NIH HHS R21 AI137446NIDCR NIH HHS R01 DE014711NIDCR NIH HHS R01 DE019783NIDCR NIH HHS R56 DE014711NIDCR NIH HHS T90 DE021990
6 · The paper itself

Abstract

Early epidemiological studies implicated manganese (Mn) as a possible caries-promoting agent, while laboratory studies have indicated that manganese stimulates the expression of virulence-related factors in the dental pathogen

Indexed as

Genetic FitnessOperonBacterial ProteinsBiofilmsBiological TransportCation Transport ProteinsDental CariesDNA, BacterialGene Expression Regulation, BacterialHumansManganeseSequence Analysis, RNAStreptococcus mutansBacterial ProteinsCation Transport ProteinsDNA, BacterialManganeseMntH protein, bacteriabiofilmdental cariesmanganesemetal transportS. mutansStreptococcus mutansstress response

Identifiers

PMID31915219
PMCPMC6952196
OpenAlexW2998790578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.