Evidence map›Paper›PMID 31915217›Full record

ArticlemSphere2020

Dietary Xanthan Gum Alters Antibiotic Efficacy against the Murine Gut Microbiota and Attenuates

Matthew K Schnizlein, Kimberly C Vendrov, Summer J Edwards, Eric C Martens, Vincent B Young

Abstract read
In one paragraph

Article in mSphere, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
  2. Review
  3. Gut microbes · 2025
    Article
  4. The emerging view on the roles of butyrate inInfection and immunity · 2025
    Review
  5. Review
  6. iMetaOmics · 2025
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Antibiotic perturbations to the gut microbiome.Nature reviews. Microbiology · 2023
    Review
  12. Recurrent Clostridioides difficile Infection: Current Clinical Management and Microbiome-Based Therapies.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2023
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matthew K SchnizleinDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-0797-8357
Kimberly C VendrovDepartment of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-9131-5272
Summer J EdwardsDepartment of Internal Medicine, Division of Infectious Diseases, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0003-0177-7850
Eric C MartensDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA.
Vincent B YoungDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA youngvi@umich.edu.ORCID 0000-0003-3687-2364

Funding

University of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OWYANG, CHUNG · 1986 to 2021
$22.5M
Systems biology of Clostridium difficile infectionU01AI124255 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SCHLOSS, PATRICK DAVID, YOUNG, VINCENT B · 2016 to 2020
$9.8M
Training in Basic and Translational Digestive SciencesT32DK094775 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN Y KAO, LINDA C. SAMUELSON · 2012 to 2026
$3.6M
NIAID NIH HHS U01 AI124255NIDDK NIH HHS P30 DK034933NIDDK NIH HHS T32 DK094775
6 · The paper itself

Abstract

Dietary fiber provides a variety of microbiota-mediated benefits ranging from anti-inflammatory metabolites to pathogen colonization resistance. A healthy gut microbiota protects against

Indexed as

AnimalsAnti-Bacterial AgentsCefoperazoneClostridioides difficileClostridium InfectionsDietary FiberDietary SupplementsDisease SusceptibilityFecesFemaleGastrointestinal MicrobiomeMaleMiceMice, Inbred C57BLPolysaccharides, BacterialSpecific Pathogen-Free OrganismsAnti-Bacterial AgentsCefoperazoneDietary FiberPolysaccharides, Bacterialxanthan gumClostridioides difficiledietary fibermicrobial ecologyxanthan gum

Identifiers

PMID31915217
PMCPMC6952194

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.