ArticleThe British journal of nutrition2020
Inulin from Jerusalem artichoke tubers alleviates hyperglycaemia in high-fat-diet-induced diabetes mice through the intestinal microflora improvement.
Article in The British journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 57 citations in OpenAlex.
- Trial
- Mulberry Polyphenols Ameliorate Metabolic Abnormalities Accompanied by Spatial Microbial and Short-Chain Fatty Acid Alterations in Type 2 Diabetic Mice.Foods (Basel, Switzerland) · 2026Article
- Modulation of Glycemic Control byFoods (Basel, Switzerland) · 2026Article
- Phytochemical Composition and Mechanistic Pharmacology of Jerusalem Artichoke (Current issues in molecular biology · 2026Review
- Phytochemical Insights and Biological Potential of thePlants (Basel, Switzerland) · 2026Review
- Resistant starches from dietary pulses improve neurocognitive health via gut-microbiome-brain axis in aged mice.Frontiers in nutrition · 2024Article
- Inulin protects against the harmful effects of dietary emulsifiers on mice gut microbiome.PeerJ · 2024Article
- The impact of high polymerization inulin on body weight reduction in high-fat diet-induced obese mice: correlation with cecalFrontiers in microbiology · 2024Article
- Perigestational exposure of a combination of a high-fat diet and pesticide impacts the metabolic and microbiotic status of dams and pups; a preventive strategy based on prebiotics.European journal of nutrition · 2023Article
- The Role of Gut Microbiota in High-Fat-Diet-Induced Diabetes: Lessons from Animal Models and Humans.Nutrients · 2023Review
- Dietary fiber modulates gut microbiome and metabolome in a host sex-specific manner in a murine model of aging.Frontiers in molecular biosciences · 2023Article
- Can Psyllium Alleviate Colitis?Cellular and molecular gastroenterology and hepatology · 2023Article
- Restoration of cefixime-induced gut microbiota changes by a prebiotic blend in a mouse model.Applied microbiology and biotechnology · 2022Article
- Administration of Jerusalem artichoke reduces the postprandial plasma glucose and glucose-dependent insulinotropic polypeptide (GIP) concentrations in humans.Food & nutrition research · 2022Article
- Dietary supplementation of inulin alleviates metabolism disorders in gestational diabetes mellitus mice via RENT/AKT/IRS/GLUT4 pathway.Diabetology & metabolic syndrome · 2021Article
- Inulin and isomalto-oligosaccharide alleviate constipation and improve reproductive performance by modulating motility-related hormones, short-chain fatty acids, and feces microflora in pregnant sows.Journal of animal science · 2021Article
- Article
- The Protective Effect of Cynara Cardunculus Extract in Diet-Induced NAFLD: Involvement of OCTN1 and OCTN2 Transporter Subfamily.Nutrients · 2020Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rate of hyperglycaemia in people around the world is increasing at an alarming rate at present, and innovative methods of alleviating hyperglycaemia are needed. The effects of Jerusalem artichoke inulin on hyperglycaemia, liver-related genes and the intestinal microbiota in mice fed a high-fat diet (HFD) and treated with streptozotocin (STZ) to induce hyperglycaemia were investigated. Inulin-treated hyperglycaemic mice had decreased average daily food consumption, body weight, average daily water consumption and relative liver weight and blood concentrations of TAG, total cholesterol, HDL-cholesterol and fasting blood glucose. Liver-related gene expressions in hyperglycaemic (HFD-fed and STZ-treated) compared with control mice showed eighty-four differentially expressed genes (forty-nine up-regulated and thirty-five down-regulated). In contrast, hyperglycaemic mice treated with inulin had twenty-two differentially expressed genes compared with control ones. Using Illumina high-throughput sequencing technology, the rarefaction and the rank abundance curves as well as the α diversity indices showed the treatment-induced differences in bacterial diversity in intestine. The linear discriminant analysis of effect size showed that the inulin treatment improved intestinal microbiota; in particular, it significantly increased the number of Bacteroides in the intestine of mice. In conclusion, inulin is potentially an effective functional food for the prevention and/or treatment of hyperglycaemia.
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Registered trials
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