Evidence map›Paper›PMID 31915072›Full record

ArticleTrials2020

Lessening Organ dysfunction with VITamin C (LOVIT): protocol for a randomized controlled trial.

Marie-Hélène Masse, Julie Ménard, Sheila Sprague, Marie-Claude Battista, Deborah J Cook, Gordon H Guyatt, Daren K Heyland, Salmaan Kanji, Ruxandra Pinto, Andrew G Day and 31 more

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03680274 (Lessening Organ Dysfunction With VITamin C), which is not on this map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03680274 phase3completednot on this map

Lessening Organ Dysfunction With VITamin C (LOVIT)

TypeinterventionalSponsorUniversité de SherbrookeRan2018 to 2022Enrolled872ConditionsSepsis, Vitamin C, Intensive Care Unit, COVID-19ArmsVitamin C, Control
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Any Role of High-Dose Vitamin C for Septic Shock in 2021?Seminars in respiratory and critical care medicine · 2021
    Article
  11. Article
  12. Article
  13. Critical Care Epidemiology and Research in the Face of a Pandemic: An Opportunity in a Crisis.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020
    Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 15 institutions in 5 countries.

Marie-Hélène MasseCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Julie MénardCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Sheila SpragueDivision of Orthopaedic Surgery, Department of Surgery, McMaster University, Hamilton, ON, Canada.
Marie-Claude BattistaCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke Sherbrooke and Université de Sherbrooke, Sherbrooke, QC, Canada.
Deborah J CookDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Gordon H GuyattDepartment of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Daren K HeylandDepartment of Critical Care Medicine, Queen's University, Kingston, ON, Canada.
Salmaan KanjiDepartments of Pharmacy and Critical Care, The Ottawa Hospital and Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.
Ruxandra PintoDepartment of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Andrew G DayKingston General Health Research Institute, Kingston, ON, Canada.
Dian CohenNo institutional affiliation, No institutional affiliation, Sherbrooke, QC, Canada.
Djillali AnnaneGeneral Intensive Care Unit, Raymond Poincaré Hospital (AP-HP), Lab Inflammation & Infection, U1173 University Paris Saclay-UVSQ/INSERM, Garches, France.
Shay McGuinnessCardiothoracic and Vascular ICU, Auckland City Hospital, Auckland, New Zealand.
Rachael ParkeCardiothoracic and Vascular ICU, Auckland City Hospital, Auckland, New Zealand.
Anitra CarrDepartment of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
Yaseen ArabiCollege of Medicine, King Saud Bin Abdulaziz University for Health Sciences, King Abdullah International Medical Research Center, Riyadh, Saudi Arabia.
Bharath Kumar Tirupakuzhi VijayaraghavanDepartment of Critical Care Medicine, Apollo Hospitals, Chennai, India.
Frédérick D'AragonCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke Sherbrooke and Université de Sherbrooke, Sherbrooke, QC, Canada.
Élaine CarbonneauCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
David MasloveDepartment of Critical Care Medicine, Queen's University and Kingston Health Sciences Centre, Kingston, ON, Canada.
Miranda HuntDepartment of Critical Care Medicine, Queen's University and Kingston Health Sciences Centre, Kingston, ON, Canada.
Bram RochwergDepartment of Medicine and Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada.
Tina MillenJuravinski Hospital, Hamilton, ON, Canada.
Michaël ChasséCentre de Recherche du Centre Hospitalier Universitaire de Montréal, Montréal, QC, Canada.
Martine LebrasseurCentre de Recherche du Centre Hospitalier Universitaire de Montréal, Montréal, QC, Canada.
Patrick ArchambaultFaculté de Médecine, Université Laval, Québec City, QC, Canada.
Estel DebloisDépartement des soins intensifs du Centre intégré de santé et des services sociaux de Chaudière-Appalaches (Secteur Alphonse-Desjardins), Lévis, QC, Canada.
Christine DrouinDepartment of Critical Care Research, St. Joseph's Healthcare, Hamilton, ON, Canada.
François LelloucheDepartment of Medecine, Université Laval and Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Québec City, QC, Canada.
Patricia LizotteInstitut Universitaire de Cardiologie et de Pneumologie de Québec, Québec City, QC, Canada.
Irene WatpoolOttawa Hospital Research Institute, Ottawa, ON, Canada.
Rebecca PorteousOttawa Hospital Research Institute, Ottawa, ON, Canada.
France ClarkeDepartment of Critical Care Research, St. Joseph's Healthcare, Hamilton, ON, Canada.
Nicole MarinoffDepartment of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Émilie Belley-CôtéDivision of Cardiology, Department of Medicine, McMaster University, Population Health Research Institute, Hamilton, ON, Canada.
Brigitte BolducCentre Hospitalier Universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Scott WalkerDepartment of Pharmacy, Sunnybrook Health Sciences Centre, Toronto, Canada and Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.
John IazzettaDepartment of Pharmacy, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.
Neill K J AdhikariDepartment of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, ON, Canada. neill.adhikari@utoronto.ca.ORCID http://orcid.org/0000-0003-4038-5382
François LamontagneCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke Sherbrooke and Université de Sherbrooke, Sherbrooke, QC, Canada. francois.lamontagne@usherbrooke.ca.
Canadian Critical Care Trials Group
Sunnybrook Health Science Centre · CACentre Hospitalier Universitaire de Sherbrooke · CAQueen's University · CAUniversité de Sherbrooke · CAOttawa Hospital · CACentre Hospitalier de l’Université de Montréal · CACentre intégré de santé et de services sociaux de Chaudière-Appalaches · CAInserm · FRJuravinski Hospital · CAKing Saud bin Abdulaziz University for Health Sciences · SAAuckland City Hospital · NZImpact · CAInstitut universitaire de cardiologie et de pneumologie de Québec · CAKingston Health Sciences Centre · CAUniversity of Auckland · NZ

Funding

Lotte and John Hecht Memorial Foundation 4318
6 · The paper itself

Abstract

backgroundSepsis is a health problem of global importance; treatments focus on controlling infection and supporting failing organs. Recent clinical research suggests that intravenous vitamin C may decrease mortality in sepsis. We have designed a randomized controlled trial (RCT) to ascertain the effect of vitamin C on the composite endpoint of death or persistent organ dysfunction at 28 days in patients with sepsis.

methodsLOVIT (Lessening Organ dysfunction with VITamin C) is a multicenter, parallel-group, blinded (participants, clinicians, study personnel, Steering Committee members, data analysts), superiority RCT (minimum n = 800). Eligible patients have sepsis as the diagnosis for admission to the intensive care unit (ICU) and are receiving vasopressors. Those admitted to the ICU for more than 24 h are excluded. Eligible patients are randomized to high-dose intravenous vitamin C (50 mg/kg every 6 h for 96 h) or placebo. The primary outcome is a composite of death or persistent organ dysfunction (need for vasopressors, invasive mechanical ventilation, or new and persisting renal replacement therapy) at day 28. Secondary outcomes include persistent organ dysfunction-free days to day 28, mortality and health-related quality of life at 6 months, biomarkers of dysoxia, inflammation, infection, endothelial function, and adverse effects (hemolysis, acute kidney injury, and hypoglycemia). Six subgroup analyses are planned. DISCUSSION: This RCT will provide evidence of the effect of high-dose intravenous vitamin C on patient-important outcomes in patients with sepsis.

trial registrationclinicaltrials.gov, NCT03680274, first posted 21 September 2018.

Indexed as

Acute Kidney InjuryAdministration, IntravenousAdultAntioxidantsAscorbic AcidClinical Trials, Phase III as TopicDose-Response Relationship, DrugDrug Therapy, CombinationFemaleHemolysisHospital MortalityHumansHypoglycemiaIntensive Care UnitsMaleMiddle AgedAntioxidantsAscorbic AcidVasoconstrictor Agentsbiomarkersrandomized controlled trialsepsisseptic shockvitamin C

Identifiers

PMID31915072
PMCPMC6950903
OpenAlexW2999905014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.