Evidence map›Paper›PMID 31915053›Full record

ArticleClinical epigenetics2020

Epigenome-wide association study of seizures in childhood and adolescence.

Doretta Caramaschi, Charlie Hatcher, Rosa H Mulder, Janine F Felix, Charlotte A M Cecil, Caroline L Relton, Esther Walton

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 19 citations in OpenAlex.

  1. Pooled it
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  5. Review
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  10. Length Polymorphism and Methylation Status of UPS29 Minisatellite of theInternational journal of molecular sciences · 2020
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Doretta CaramaschiBristol Medical School, Population Health Sciences, University of Bristol, 5 Tyndall Avenue, Bristol, BS8 1UD, UK. D.Caramaschi@bristol.ac.uk.ORCID 0000-0002-9740-871X
Charlie HatcherBristol Medical School, Population Health Sciences, University of Bristol, 5 Tyndall Avenue, Bristol, BS8 1UD, UK.
Rosa H MulderInstitute of Education and Child Studies, Leiden University, Pieter de la Court building, Wassenaarseweg 52, 2333, AK, Leiden, The Netherlands.
Janine F FelixGeneration R Study Group, Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015, GD, Rotterdam, The Netherlands.
Charlotte A M CecilDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015, GD, Rotterdam, The Netherlands.
Caroline L ReltonBristol Medical School, Population Health Sciences, University of Bristol, 5 Tyndall Avenue, Bristol, BS8 1UD, UK.
Esther WaltonBristol Medical School, Population Health Sciences, University of Bristol, 5 Tyndall Avenue, Bristol, BS8 1UD, UK.
University of Bristol · GBErasmus MC · NLLeiden University · NL

Funding

Epigenetic Pathways to Conduct Problem Trajectories: Early Environmental RisksR01HD068437 · NICHD · KING'S COLLEGE LONDON · PI BARKER, EDWARD D., MILL, JONATHAN · 2012 to 2014
$1.1M
Biotechnology and Biological Sciences Research Council (GB) BB/I025263/1Biotechnology and Biological Sciences Research Council (GB) BB/I025751/1Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Medical Research Council MC_UU_00011/1Medical Research Council MC_UU_00011/5Medical Research Council MC_UU_12013/2NICHD NIH HHS R01 HD068437Wellcome TrustWellcome Trust 102215/2/13/2Wellcome Trust 108902/B/15/Z
6 · The paper itself

Abstract

The occurrence of seizures in childhood is often associated with neurodevelopmental impairments and school underachievement. Common genetic variants associated with epilepsy have been identified and epigenetic mechanisms have also been suggested to play a role. In this study, we analyzed the association of genome-wide blood DNA methylation with the occurrence of seizures in ~ 800 children from the Avon Longitudinal Study of Parents and Children, UK, at birth (cord blood), during childhood, and adolescence (peripheral blood). We also analyzed the association between the lifetime occurrence of any seizures before age 13 with blood DNA methylation levels. We sought replication of the findings in the Generation R Study and explored causality using Mendelian randomization, i.e., using genetic variants as proxies. The results showed five CpG sites which were associated cross-sectionally with seizures either in childhood or adolescence (1-5% absolute methylation difference at p

Indexed as

AdolescentBirth WeightBrain-Derived Neurotrophic FactorChildDNADNA MethylationEpigenesis, GeneticFemaleFetal BloodGenome-Wide Association StudyGestational AgeHumansLongitudinal StudiesMaleMendelian Randomization AnalysisNeurodevelopmental DisordersBDNF protein, humanBrain-Derived Neurotrophic FactorDNAALSPACDNA methylationEpigeneticsEpilepsyGeneration R StudyIllumina 450 KMendelian randomizationSeizures

Identifiers

PMID31915053
PMCPMC6950851
OpenAlexW2990332022

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.