ArticleRadiation oncology (London, England)2020
Impact of genetic variant of HIPK2 on the risk of severe radiation pneumonitis in lung cancer patients treated with radiation therapy.
Article in Radiation oncology (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02490319 (Study on the Biological Prediction Models of Radiation Pneumonitis), which is not on this map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study on the Biological Prediction Models of Radiation Pneumonitis
Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Review
- Radiation-induced lung injury: from mechanism to prognosis and drug therapy.Radiation oncology (London, England) · 2025Review
- HIPK2 as a Novel Regulator of Fibrosis.Cancers · 2023Review
- Promising Biomarkers of Radiation-Induced Lung Injury: A Review.Biomedicines · 2021Review
- Genetic variations in DNA repair gene NEIL1 associated with radiation pneumonitis risk in lung cancer patients.Molecular genetics & genomic medicine · 2021Article
- A novel nomogram containing acute radiation esophagitis predicting radiation pneumonitis in thoracic cancer receiving radiotherapy.BMC cancer · 2021Observational
- Low dose ionizing radiation effects on the immune system.Environment international · 2021Review
- Severity of radiation pneumonitis, from clinical, dosimetric and biological features: a pilot study.Radiation oncology (London, England) · 2020Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHomeodomain-interacting protein kinase 2 (HIPK2) has increasingly drawn attention as recent researches demonstrated its unique role in the regulation of multiple fundamental processes such as apoptosis, proliferation and DNA damage repair. Most importantly, HIPK2 was shown to play regulatory role in inflammation and influence the phenotype and activity of fibroblasts. In this study, we aimed to evaluate the impact of HIPK2 gene variant on risk of radiation pneumonitis for patients with pulmonary malignancies.
methods169 lung cancer patients with radiotherapy were included in our prospective study and genotyped by Sanger Sequence method. Multivariable Cox hazard analysis and multiple testing were applied to estimate the hazard ratio (HR) and 95% confidence intervals (CIs) of all factors possibly related to the risk of radiation pneumonitis (RP).
resultsPatients with Mean Lung Dose (MLD) ≥ 15Gy, Lung V
conclusionHIPK2: rs2030712 was found to be significantly related to RP of grade ≥ 2 in our cohort, and may thus be one of the important predictors of severe RP before radiotherapy, if further validated in larger population.
trial registrationOur study was prospective and observational. The research was registered in ClinicalTrials.gov database as NCT02490319.
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Registered trials
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