Evidence map›Paper›PMID 31915019›Full record

ArticleJournal of biomedical science2020

Neuropeptide S-initiated sequential cascade mediated by OX

Ming Tatt Lee, Yu-Ting Chiu, Yu-Chun Chiu, Chia Chun Hor, Hsin-Jung Lee, Remo Guerrini, Girolamo Calo, Lih-Chu Chiou

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomedical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. A Role for Neuropeptide S in Alcohol and Cocaine Seeking.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  9. Review
  10. Roles of Neuropeptide S in Anesthesia, Analgesia, and Sleep.Pharmaceuticals (Basel, Switzerland) · 2021
    Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Ming Tatt LeeGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan.
Yu-Ting ChiuGraduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan.
Yu-Chun ChiuGraduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan.
Chia Chun HorGraduate Institute of Pharmacology, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan.
Hsin-Jung LeeDepartment of Pharmacology, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan.
Remo GuerriniDepartment of Chemical and Pharmaceutical Sciences, Laboratorio per le Tecnologie delle Terapie Avanzate (LTTA), Ferrara, Italy.
Girolamo CaloDepartment of Medical Sciences and National Institute of Neurosciences, Section of Pharmacology, University of Ferrara, 44121, Ferrara, Italy.
Lih-Chu ChiouGraduate Institute of Brain and Mind Sciences, College of Medicine, National Taiwan University, Taipei, 10051, Taiwan. lcchiou@ntu.edu.tw.ORCID http://orcid.org/0000-0001-5356-940X
National Taiwan University · TWTecnologie Avanzate (Italy) · ITUniversity of Ferrara · IT

Funding

Ministry of Education 107M4022-3Ministry of Science and Technology, Taiwan MOST104-2314-B-002-053-MY3, MOST106-2321-B-002-019, MOST106-2811-B-002-124, MOST107-2321-B-002-010, MOST107-2811-B-002-008, MOST 108-2321-B-002-005 and MOST 108-2320-B-002-029-MY3National Health Research Institutes NHRI-EX102-10251NI, NHRI-EX107-10733NI
6 · The paper itself

Abstract

backgroundStress-induced analgesia (SIA) is an evolutionarily conserved phenomenon during stress. Neuropeptide S (NPS), orexins, substance P, glutamate and endocannabinoids are known to be involved in stress and/or SIA, however their causal links remain unclear. Here, we reveal an unprecedented sequential cascade involving these mediators in the lateral hypothalamus (LH) and ventrolateral periaqueductal gray (vlPAG) using a restraint stress-induced SIA model.

methodsMale C57BL/6 mice of 8-12 week-old were subjected to intra-cerebroventricular (i.c.v.) and/or intra-vlPAG (i.pag.) microinjection of NPS, orexin-A or substance P alone or in combination with selective antagonists of NPS receptors (NPSRs), OX

resultsNPS (i.c.v., but not i.pag.) induced antinociception. This effect was prevented by i.c.v. blockade of NPSRs. Substance P (i.pag.) and orexin-A (i.pag.) also induced antinociception. Substance P (i.pag.)-induced antinociception was prevented by i.pag. Blockade of NK

conclusionsThese results suggest that, during stress, NPS is released and activates LH orexin neurons via NPSRs, releasing orexins in the vlPAG. Orexins then activate OX

Indexed as

AnalgesiaAnimalsMaleMiceNeuropeptidesOrexin ReceptorsReceptor, Cannabinoid, CB1Receptor, Metabotropic Glutamate 5Stress, PsychologicalVentral Thalamic NucleiGrm5 protein, mouseHcrtr1 protein, mouseNeuropeptidesneuropeptide S, mouseOrexin ReceptorsReceptor, Cannabinoid, CB1Receptor, Metabotropic Glutamate 5EndocannabinoidMetabotropic glutamate receptorNeuropeptide SOrexinPeriaqueductal graySubstance P

Identifiers

PMID31915019
PMCPMC6950992
OpenAlexW3008954383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.