Evidence map›Paper›PMID 31914785›Full record

ArticleAIDS research and human retroviruses2020

A Summary of the Fourth Annual Virology Education HIV Microbiome Workshop.

Brett Williams, Mimi Ghosh, Charles Boucher, Frederic Bushman, Stacy Carrington-Lawrence, Ronald G Collman, Satya Dandekar, Que Dang, Angela Malaspina, Roger Paredes and 6 more

Open access · greenAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 3 countries.

Brett WilliamsDivision of Infectious Diseases, Rush University Medical Center, Chicago, Illinois, USA.
Mimi GhoshDepartment of Epidemiology and Biostatistics, The George Washington University, Washington, District of Columbia, USA.
Charles BoucherDepartment of Virosciences, Erasmus Medical Center, Erasmus University Rotterdam, Rotterdam, the Netherlands.
Frederic BushmanDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Stacy Carrington-LawrenceOffice of AIDS Research, Division of Program Coordination, Planning, and Strategic Initiatives, Office of the Director, U.S. National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, Maryland, USA.
Ronald G CollmanDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Satya DandekarDepartment of Medical Microbiology and Immunology, University of California, Davis, Davis, California, USA.
Que DangVaccine Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Angela MalaspinaVaccine Research Program, Division of AIDS, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA.
Roger ParedesInstitut de Recerca de la SIDA IrsiCaixa i Unitat VIH, Universitat Autònoma de Barcelona, Universitat de Vic, Catalonia, Spain.
Cara WilsonDepartment of Medicine, University of Colorado Denver, Denver, Colorado, USA.
Sandra Pinto CardosoCenter for Research in Infectious Diseases, National Institute of Respiratory Diseases, Mexico City, Mexico.
Laurel LagenaurOsel, Inc., Mountain View, California, USA.
Jessica SantosColumbus Technologies and Services, Inc., NIAID/NIH, Bethesda, Maryland, USA.
Christopher JoyDepartment of Epidemiology and Biostatistics, The George Washington University, Washington, District of Columbia, USA.
Alan LandayDivision of Gerontology, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA.
George Washington University · USNational Institute of Allergy and Infectious Diseases · USRush University Medical Center · USUniversity of Pennsylvania · USColumbus Technologies and Services (United States) · USDivision of Program Coordination Planning and Strategic Initiatives · USErasmus University Rotterdam · NLOsel (United States) · USUniversitat de Vic - Universitat Central de Catalunya · ESUniversity of California, Davis · USUniversity of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Each year, a growing international collection of researchers meets at the NIH to share and discuss developments in the microbiome HIV story. This past year has seen continued progress toward a detailed understanding of host-microbe interactions both within and outside the field of HIV. Commensal microbes are being linked to an ever-growing list of maladies and physiologic states, including major depressive disorder, chronic kidney disease, and Parkinson disease. PubMed citations for "microbiome" are growing at an exponential rate with over 11,000 in 2018. Various microbial taxa have been associated with HIV infection, and some of these taxa associated with HIV infection have also been associated with systemic markers of inflammation in HIV infected individuals. Causality remains unclear however as environmental and behavioral factors may drive HIV risk, inflammation, and gut enterotype. Much of the work currently being done addresses potential mechanisms by which gut microbes influence immune and inflammatory pathways. No portion of the microbiome landscape has grown as rapidly as study of the interplay between gut microbes and response to cancer immunotherapy. As Dr. Wargo discussed in her keynote address, this area has opened the door to better understanding on how commensal microbes interact with the human immune system.

Indexed as

Gastrointestinal MicrobiomeBacterial TranslocationCongresses as TopicDysbiosisHIV InfectionsHumansSymbiosisVirologycomorbiditiesHIVimmune activationmicrobial translocationmicrobiomemucosal immunology

Identifiers

PMID31914785
PMCPMC7360108
OpenAlexW4237960104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.