Evidence map›Paper›PMID 31914706›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020

Plasmin inhibition by bacterial serpin: Implications in gum disease.

Alicja Sochaj-Gregorczyk, Miroslaw Ksiazek, Irena Waligorska, Anna Straczek, Malgorzata Benedyk, Danuta Mizgalska, Ida B Thøgersen, Jan J Enghild, Jan Potempa

Open access · greenAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Serpins in Tick Physiology and Tick-Host Interaction.Frontiers in cellular and infection microbiology · 2022
    Review
  9. Article
  10. Review
  11. Gut Serpinome: Emerging Evidence in IBD.International journal of molecular sciences · 2021
    Review
  12. Assessing Plasmin Generation in Health and Disease.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Alicja Sochaj-GregorczykMalopolska Center of Biotechnology, Jagiellonian University, Krakow, Poland.
Miroslaw KsiazekMalopolska Center of Biotechnology, Jagiellonian University, Krakow, Poland.
Irena WaligorskaDepartment of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.
Anna StraczekDepartment of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.
Malgorzata BenedykDepartment of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.
Danuta MizgalskaDepartment of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.
Ida B ThøgersenInterdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology, Aarhus University, Aarhus, Denmark.
Jan J EnghildInterdisciplinary Nanoscience Center (iNANO), Department of Molecular Biology, Aarhus University, Aarhus, Denmark.
Jan PotempaDepartment of Microbiology, Faculty of Biochemistry, Biophysics, and Biotechnology, Jagiellonian University, Krakow, Poland.
Jagiellonian University · PLAarhus University · DKUniversity of Louisville · US

Funding

Bacterial peptidylarginine deiminase, a link between gums and joint diseaseR01DE022597 · NIDCR · UNIVERSITY OF LOUISVILLE · PI POTEMPA, JAN S · 2013 to 2023
$3.7M
Protease - protease inhibitor system of Tannerella forsythiaR21DE026280 · NIDCR · UNIVERSITY OF LOUISVILLE · PI POTEMPA, JAN S · 2016 to 2017
$424k
NIDCR NIH HHS R01 DE022597NIDCR NIH HHS R21 DE026280NIH/NIDCR R21DE026280
6 · The paper itself

Abstract

Tannerella forsythia is a periodontopathogen that expresses miropin, a protease inhibitor in the serpin superfamily. In this study, we show that miropin is also a specific and efficient inhibitor of plasmin; thus, it represents the first proteinaceous plasmin inhibitor of prokaryotic origin described to date. Miropin inhibits plasmin through the formation of a stable covalent complex triggered by cleavage of the Lys

Indexed as

AnimalsAntifibrinolytic AgentsBacteriaCatalytic DomainFemaleFibrinolysinFibrinolysisHumansMice, Inbred C57BLPeriodontal DiseasesProtease InhibitorsSerpinsAntifibrinolytic AgentsFibrinolysinProtease InhibitorsSerpinsfibrinolysisperiodontitisplasminserpinTannerella forsythia

Identifiers

PMID31914706
PMCPMC8882047
OpenAlexW2990561778

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.