Evidence map›Paper›PMID 31914705›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020

Resolvin D1 promotes efferocytosis in aging by limiting senescent cell-induced MerTK cleavage.

Nicholas Rymut, Justin Heinz, Sudeshna Sadhu, Zeinab Hosseini, Colin O Riley, Michael Marinello, Jackson Maloney, Katherine C MacNamara, Matthew Spite, Gabrielle Fredman

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 107 citations in OpenAlex.

  1. Article
  2. Defective efferocytosis in diabetes: molecular mechanisms and emerging therapeutic strategies.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  3. Article
  4. Review
  5. Suppression of cardiac allograft vasculopathy by a macrophage efferocytosis receptor.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
    Article
  6. Review
  7. Article
  8. More Than a Cleanup Crew: The Expanding Biology of Efferocytosis.Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. Article

14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Nicholas RymutThe Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Justin HeinzThe Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Sudeshna SadhuThe Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Zeinab HosseiniThe Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Colin O RileyDepartment of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Michael MarinelloThe Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Jackson MaloneyThe Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA.
Katherine C MacNamaraThe Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA.
Matthew SpiteDepartment of Anesthesiology, Perioperative and Pain Medicine, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Gabrielle FredmanThe Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
Albany Medical Center Hospital · USBrigham and Women's Hospital · US

Funding

Resolution Mechanisms in Acute Inflammation: Resolution PharmacologyP01GM095467 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI PETASIS, NICOS A · 2011 to 2020
$14.8M
Role of Inflammation-Resolving Lipid Mediators In Ischemic RevascularizationR01HL106173 · NHLBI · UNIVERSITY OF LOUISVILLE · PI SPITE, MATTHEW R · 2011 to 2023
$5.7M
Necroptosis Impairs Inflammation-Resolution Programs in AtherosclerosisR01HL141127 · NHLBI · ALBANY MEDICAL COLLEGE · PI FREDMAN, GABRIELLE · 2018 to 2022
$2.2M
Hematopoietic Stem Cell Dysfunction and Regeneration in Severe InfectionR35GM131842 · NIGMS · ALBANY MEDICAL COLLEGE · PI MACNAMARA, KATHERINE C. · 2019 to 2023
$2.0M
HSC function during infectionR01GM105949 · NIGMS · ALBANY MEDICAL COLLEGE · PI MACNAMARA, KATHERINE C. · 2014 to 2018
$1.5M
Specialized pro-resolving mediators in atherosclerosisR00HL119587 · NHLBI · ALBANY MEDICAL COLLEGE · PI FREDMAN, GABRIELLE · 2015 to 2017
$731k
Specialized pro-resolving mediators in atherosclerosisK99HL119587 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FREDMAN, GABRIELLE · 2013 to 2014
$216k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL106173HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM095467HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM105949NHLBI NIH HHS K99 HL119587NHLBI NIH HHS R00 HL119587NHLBI NIH HHS R01 HL106173NHLBI NIH HHS R01 HL141127NIGMS NIH HHS P01 GM095467NIGMS NIH HHS R01 GM105949NIGMS NIH HHS R35 GM131842
6 · The paper itself

Abstract

Inflammation-resolution is mediated by the balance between specialized pro-resolving mediators (SPMs) like resolvin D1 (RvD1) and pro-inflammatory factors, like leukotriene B

Indexed as

AgingAnimalsCellular Senescencec-Mer Tyrosine KinaseDocosahexaenoic AcidsInflammationMacrophagesMaleMice, Inbred C57BLMice, TransgenicNeutrophilsPeritonitisPhagocytosisReceptor Protein-Tyrosine KinasesReperfusion Injuryc-Mer Tyrosine KinaseDocosahexaenoic AcidsMertk protein, mouseReceptor Protein-Tyrosine Kinasesresolvin D1efferocytosisinflammation‐resolutionMerTKresolvinSASP

Identifiers

PMID31914705
PMCPMC6956736
OpenAlexW2990221960

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.