Evidence map›Paper›PMID 31914647›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020

Improving natural product research translation: From source to clinical trial.

Barbara C Sorkin, Adam J Kuszak, Gregory Bloss, Naomi K Fukagawa, Freddie Ann Hoffman, Mahtab Jafari, Bruce Barrett, Paula N Brown, Frederic D Bushman, Steven J Casper and 22 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 89 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Review
  6. Phytochemical Composition of Clonally PropagatedMolecules (Basel, Switzerland) · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Evaluation ofFrontiers in pharmacology · 2026
    Article
  12. Review
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  14. Article
  15. Article
  16. Article
  17. Article
  18. Gels (Basel, Switzerland) · 2025
    Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors at 20 institutions in 4 countries.

Barbara C SorkinOffice of Dietary Supplements, National Institutes of Health (NIH), Bethesda, MD, USA.
Adam J KuszakOffice of Dietary Supplements, National Institutes of Health (NIH), Bethesda, MD, USA.
Gregory BlossNational Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, MD, USA.
Naomi K FukagawaUSDA ARS, Beltsville, MD, USA.
Freddie Ann HoffmanHeteroGeneity LLC, Washington, DC, USA.
Mahtab JafariUniversity of California, Irvine, Irvine, CA, USA.
Bruce BarrettUniversity of Wisconsin, Madison, WI, USA.
Paula N BrownBritish Columbia Institute of Technology, Burnaby, BC, Canada.
Frederic D BushmanUniversity of Pennsylvania, Philadelphia, PA, USA.
Steven J CasperOffice of Dietary Supplement Programs, Center for Food Safety and Applied Nutrition, Food and Drug Administration (FDA), Hyattsville, MD, USA.
Floyd H ChiltonDepartment of Nutritional Sciences and the BIO5 Institute, University of Arizona, Tucson, AZ, USA.
Christopher S CoffeyUniversity of Iowa, Iowa City, IA, USA.
Mario G FerruzziPlants for Human Health Institute, North Carolina State University, Kannapolis, NC, USA.
D Craig HoppNational Center for Complementary and Integrative Health, NIH, Bethesda, MD, USA.
Mairead KielyCork Centre for Vitamin D and Nutrition Research, School of Food and Nutritional Sciences, University College Cork, Cork, Ireland.
Daniel LakensEindhoven University of Technology, Eindhoven, Netherlands.
John B MacMillanUniversity of California, Santa Cruz, Santa Cruz, CA, USA.
David O MeltzerUniversity of Chicago Medicine, Chicago, IL, USA.
Marco PahorUniversity of Florida, Gainesville, FL, USA.
Jeffrey PaulDrexel Graduate College of Biomedical Sciences, College of Medicine, Evanston, IL, USA.
Kathleen Pritchett-CorningHarvard University, Cambridge, MA, USA.
Sara K QuinneyIndiana University, Indianapolis, IN, USA.
Barbara RehermannNational Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, MD, USA.
Kenneth D R SetchellCincinnati Children's Hospital, Cincinnati, OH, USA.
Nisha S SipesNational Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, USA.
Jacqueline M StephensLouisiana State University, Baton Rouge, LA, USA.
D Lansing TaylorUniversity of Pittsburgh, Pittsburgh, PA, USA.
Hervé TiriacUniversity of California, San Diego, La Jolla, CA, USA.
Michael A WaltersInstitute for Therapeutics Discovery and Development, University of Minnesota, Minneapolis, MN, USA.
Dan XiOffice of Cancer Complementary and Alternative Medicine, National Cancer Institute, NIH, Shady Grove, MD, USA.
Giovanna ZappaláNational Institute on Aging, NIH, Bethesda, MD, USA.
Guido F PauliCENAPT and PCRPS, University of Illinois at Chicago College of Pharmacy, Chicago, IL, USA.
National Center for Complementary and Integrative Health · USBeltsville Agricultural Research Center · USBritish Columbia Institute of Technology · CACenter for Food Safety and Applied Nutrition · USCincinnati Children's Hospital Medical Center · USDrexel University · USEindhoven University of Technology · NLHarvard University Press · USIndiana University IndianapolisLouisiana State University · USNational Institute of Diabetes and Digestive and Kidney Diseases · USNational Institute of Environmental Health Sciences · USNational Institute on Aging · USNational Institute on Alcohol Abuse and Alcoholism · USNational Institutes of Health · USNorth Carolina State University · USOffice of Dietary Supplements · USUniversity College Cork · IEUniversity of Arizona · USUniversity of California, Irvine · US

Funding

University of Florida Older Americans Independence Center (OAIC)P30AG028740 · NIA · UNIVERSITY OF FLORIDA · PI Stephen D Anton · 2007 to 2026
$22.8M
Regulation of hepatic and systemic immune responsesZIADK054508 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI REHERMANN, BARBARA · 2009 to 2025
$22.1M
Role of PUFA-Gene Interactions in Health DisparitiesR01AT008621 · NCCIH · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FLOYD H CHILTON, Susan Schembre · 2016 to 2026
$5.4M
Intramural NIH HHS Z99 OD999999NCCIH NIH HHS R01 AT008621NIA NIH HHS P30 AG028740
6 · The paper itself

Abstract

While great interest in health effects of natural product (NP) including dietary supplements and foods persists, promising preclinical NP research is not consistently translating into actionable clinical trial (CT) outcomes. Generally considered the gold standard for assessing safety and efficacy, CTs, especially phase III CTs, are costly and require rigorous planning to optimize the value of the information obtained. More effective bridging from NP research to CT was the goal of a September, 2018 transdisciplinary workshop. Participants emphasized that replicability and likelihood of successful translation depend on rigor in experimental design, interpretation, and reporting across the continuum of NP research. Discussions spanned good practices for NP characterization and quality control; use and interpretation of models (computational through in vivo) with strong clinical predictive validity; controls for experimental artefacts, especially for in vitro interrogation of bioactivity and mechanisms of action; rigorous assessment and interpretation of prior research; transparency in all reporting; and prioritization of research questions. Natural product clinical trials prioritized based on rigorous, convergent supporting data and current public health needs are most likely to be informative and ultimately affect public health. Thoughtful, coordinated implementation of these practices should enhance the knowledge gained from future NP research.

Indexed as

AnimalsBiological ProductsDrug Evaluation, PreclinicalEthnobotanyHumansTranslational Research, BiomedicalBiological Productsclinical predictive validitydietary supplementsmodel systemsrigor and replicabilityvalue of information

Identifiers

PMID31914647
PMCPMC7470648
OpenAlexW2996402632

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.