Evidence map›Paper›PMID 31914398›Full record

ArticleCell reports2020

Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection.

Tatsuya Dokoshi, Ling-Juan Zhang, Fengwu Li, Teruaki Nakatsuji, Anna Butcher, Hiroyuki Yoshida, Masayuki Shimoda, Yasunori Okada, Richard L Gallo

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. ALX/FPR2 Contributes to Serum Amyloid A-Induced Lung Neutrophil Recruitment Following Acute Ozone Exposure.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Article
  6. Review
  7. Hyaluronan: An Architect and Integrator for Cancer and Neural Diseases.International journal of molecular sciences · 2025
    Review
  8. The crucial role of CEMIP in cancer metastasis: Mechanistic insights and clinical implications.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. The role of nanocomposites against biofilm infections in humans.Frontiers in cellular and infection microbiology · 2023
    Review
  16. Review
  17. Article
  18. Article
  19. Highway toFrontiers in pharmacology · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Tatsuya DokoshiDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Ling-Juan ZhangDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Fengwu LiDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Teruaki NakatsujiDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Anna ButcherDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA.
Hiroyuki YoshidaBiological Science Research, Kao Corporation, Odawara-shi, Kanagawa, Japan.
Masayuki ShimodaDepartment of Pathology, Keio University School of Medicine, Tokyo, Japan.
Yasunori OkadaDepartment of Pathophysiology for Locomotive and Neoplastic Diseases, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Richard L GalloDepartment of Dermatology, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: rgallo@ucsd.edu.
University of California, San Diego · USJuntendo University · JPKao Corporation (Japan) · JPKeio University · JP

Funding

Siglec Modulation of Inflammatory ResponsesP01HL107150 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LE, DZUNG T · 2011 to 2017
$18.0M
Cathelicidins in Skin ImmunityR01AI052453 · NIAID · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI GALLO, RICHARD L, NIZET, VICTOR · 2002 to 2017
$5.3M
Cathelicidin in Skin ImmunityR37AI052453 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard L Gallo, Victor Nizet · 2019 to 2026
$4.6M
Microbiome Function in Atopic DermatitisU01AI152038 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Richard L Gallo · 2020 to 2026
$3.3M
Conflict and Cooperation between AMP Species on the skinR01AR076082 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L, NAKATSUJI, TERUAKI · 2019 to 2023
$2.3M
Skin Microbiome in epidermal immune defenseR01AI083358 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L · 2010 to 2014
$1.9M
Skin Defense by Dermal AdipocytesR01AR069653 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L · 2016 to 2020
$1.9M
Skin barrier function and the microbiomeR01AI116576 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L, NAKATSUJI, TERUAKI · 2015 to 2019
$1.7M
NHLBI NIH HHS P01 HL107150NIAID NIH HHS R01 AI052453NIAID NIH HHS R01 AI083358NIAID NIH HHS R01 AI116576NIAID NIH HHS R37 AI052453NIAID NIH HHS U01 AI152038NIAMS NIH HHS R01 AR069653NIAMS NIH HHS R01 AR076082
6 · The paper itself

Abstract

Staphylococcus aureus is a major human bacterial pathogen responsible for deep tissue skin infections. Recent observations have suggested that rapid, localized digestion of hyaluronic acid in the extracellular matrix (ECM) of the dermis may influence bacterial invasion and tissue inflammation. In this study we find that cell migration-inducing protein (Cemip) is the major inducible gene responsible for hyaluronan catabolism in mice. Cemip

Indexed as

Host-Pathogen InteractionsAdipogenesisAnimalsDermisHyaluronic AcidHyaluronoglucosaminidaseInflammationMice, Inbred C57BLMice, KnockoutStaphylococcal InfectionsStaphylococcus aureusCemip protein, mouseHyaluronic AcidHyaluronoglucosaminidaseantimicrobial peptidescathelicidindermisglycosaminoglycanshyaluronaninnate immunityskinStaphylococcus aureus

Identifiers

PMID31914398
PMCPMC7029423
OpenAlexW3000066572

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.