Evidence map›Paper›PMID 31914381›Full record

ArticleCell reports2020

CD4

Elena Brenna, Alexey N Davydov, Kristin Ladell, James E McLaren, Paolo Bonaiuti, Maria Metsger, James D Ramsden, Sarah C Gilbert, Teresa Lambe, David A Price and 4 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04568044 (Evaluation of Cell-mediated and Humoral Immunity Following COVID-19 in Pregnancy), which is not on this map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04568044 unknown statusnot on this map

Evaluation of Cell-mediated and Humoral Immunity Following COVID-19 in Pregnancy

TypeobservationalSponsorImperial College LondonRan2020 to 2025Enrolled128ConditionsCOVID-19, Pregnancy Related, Influenza, HumanArmsBlood sample
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 120 citations in OpenAlex.

  1. Protein/AS01Cell reports. Medicine · 2021
    Trial
  2. Trial
  3. Targeting T follicular helper cells for lifelong health.Nature reviews. Drug discovery · 2026
    Review
  4. T Cell Thoughts.Immunological reviews · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Circulating TFH2 Cell Expansion and GZMKJournal of asthma and allergy · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. T follicular helper cells in primary immune regulatory disorders.The Journal of allergy and clinical immunology · 2025
    Review
  14. T-cell and autoantibody profiling for primary immune regulatory disorders.The Journal of allergy and clinical immunology · 2025
    Article
  15. Article
  16. Review
  17. Activation of CXCR3Journal of virology · 2025
    Article
  18. Article
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 5 countries.

Elena BrennaNuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK. Electronic address: elena.brenna@ndm.ox.ac.uk.
Alexey N DavydovCentral European Institute of Technology, Brno 601 77, Czech Republic.
Kristin LadellDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
James E McLarenDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Paolo BonaiutiIstituto Firc di Oncologia Molecolare, Milano 20139, Italy.
Maria MetsgerCentral European Institute of Technology, Brno 601 77, Czech Republic.
James D RamsdenWest Wing ENT, John Radcliffe Hospital, Oxford OX3 9DU, UK.
Sarah C GilbertThe Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
Teresa LambeThe Jenner Institute, University of Oxford, Oxford OX3 7DQ, UK.
David A PriceDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff CF14 4XN, UK; Systems Immunity Research Institute, Cardiff University School of Medicine, Cardiff CF14 4XN, UK.
Suzanne L CampionNuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Dmitriy M ChudakovCentral European Institute of Technology, Brno 601 77, Czech Republic; Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow 117997, Russia; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Science, Moscow 117997, Russia.
Persephone BorrowNuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK. Electronic address: persephone.borrow@ndm.ox.ac.uk.
Andrew J McMichaelNuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK. Electronic address: andrew.mcmichael@ndm.ox.ac.uk.
University of Oxford · GBCardiff University · GBCentral European Institute of Technology · CZIFOM · ITJohn Radcliffe Hospital · GB

Funding

Nonhuman primate studies for development of a prototype HIV vaccine that induces broadly neutralizing antibodiesUM1AI144371 · NIAID · DUKE UNIVERSITY · PI HAYNES, BARTON F. · 2019 to 2025
$190.4M
GENE THERAPY FOR IMMUNE DEFICIENCIESZ01AI000645 · NIAID · NIAID EXTRAMURAL ACTIVITIES · PI DE RAVIN, SUK · 1992 to 2008
$873k
Intramural NIH HHS Z01 AI000645Medical Research Council MR/K012037Medical Research Council MR/K012037/1NIAID NIH HHS UM1 AI144371Wellcome TrustWellcome Trust 100326/Z/12/Z
6 · The paper itself

Abstract

T follicular helper (Tfh) cells are fundamental for B cell selection and antibody maturation in germinal centers. Circulating Tfh (cTfh) cells constitute a minor proportion of the CD4

Indexed as

AdolescentAdultCD4-Positive T-LymphocytesCell SizeClone CellsComputer SimulationHemagglutinin Glycoproteins, Influenza VirusHumansLymphocyte SubsetsMiddle AgedPalatine TonsilReceptors, CXCR3T Follicular Helper CellsTissue DonorsYoung AdultHemagglutinin Glycoproteins, Influenza VirusReceptors, CXCR3bloodinfluenzaTCR repertoireT follicular helper cellstonsil

Identifiers

PMID31914381
PMCPMC7029615
OpenAlexW2995810853

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.