Evidence map›Paper›PMID 31914227›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2020

Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration.

K B Casaletto, A M Staffaroni, A Wolf, B Appleby, D Brushaber, G Coppola, B Dickerson, K Domoto-Reilly, F M Elahi, J Fields and 31 more

2 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02372773 completednot on this map

Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects

TypeobservationalSponsorMayo ClinicRan2015 to 2020Enrolled398ConditionsFamilial Frontotemporal Dementia
NCT06181500 nacompletednot on this mapstarted 2023, after this paper: background citation

Home-Based Exercise in Primary Progressive Aphasia: A Pilot Study

TypeinterventionalSponsorMontreal Heart InstituteRan2023 to 2024Enrolled13ConditionsPrimary Progressive Aphasia, Neurodegenerative Diseases, Logopenic Progressive Aphasia, Semantic DementiaArmsHome-based multicomponent exercise intervention program
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Cognitive reserve in individuals with frontotemporal dementia: a systematic review.Journal of clinical and experimental neuropsychology · 2024
    Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Gaps in biomedical research in frontotemporal dementia: A call for diversity and disparities focused research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  11. Article
  12. Article
  13. Article
  14. New Approaches to the Treatment of Frontotemporal Dementia.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Article
  15. Article
  16. Preclinical Interventions in Mouse Models of Frontotemporal Dementia Due to Progranulin Mutations.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  17. Review
  18. Article
  19. Late-life physical activity relates to brain tissue synaptic integrity markers in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

41 authors at 19 institutions in 2 countries.

K B CasalettoMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
A M StaffaroniMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
A WolfMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
B ApplebyCase Western Reserve University, Cleveland, Ohio, USA.
D BrushaberMayo Clinic, Rochester, Minnesota, USA.
G CoppolaUniversity of California, Los Angeles, California, USA.
B DickersonDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.
K Domoto-ReillyUniversity of Washington, Seattle, Washington, USA.
F M ElahiMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
J FieldsMayo Clinic, Rochester, Minnesota, USA.
J C FongMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
L ForsbergCase Western Reserve University, Cleveland, Ohio, USA.
N GhoshalWashington University, St. Louis, Illinois, USA.
N Graff-RadfordMayo Clinic, Rochester, Minnesota, USA.
M GrossmanUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
H W HeuerMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
G-Y HsiungUniversity of British Columbia, Vancouver, British Columbia, Canada.
E D HueyColumbia University, New York, New York, USA.
D IrwinUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
K KantarciMayo Clinic, Rochester, Minnesota, USA.
D KauferUniversity of North Carolina, Chapel Hill, North Carolina, USA.
D KerwinUniversity of Texas Southwestern, Dallas, Texas, USA.
D KnopmanMayo Clinic, Rochester, Minnesota, USA.
J KornakDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
J H KramerMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
I LitvanParkinson and Other Movement Disorder Center, Department of Neuroscience, University of California, San Diego, San Diego, California, USA.
I R MackenzieUniversity of British Columbia, Vancouver, British Columbia, Canada.
M MendezUniversity of California, Los Angeles, California, USA.
B MillerMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
R RademakersMayo Clinic, Jacksonville, Florida, USA.
E M RamosUniversity of California, Los Angeles, USA.
K RascovskyUniversity of Pennsylvania, Philadelphia, Pennsylvania, USA.
E D RobersonUniversity of Alabama, Birmingham, Alabama, USA.
J A SyrjanenMayo Clinic, Rochester, Minnesota, USA.
M C TartagliaUniversity of Toronto, Toronto, Ontario, Canada.
S WeintraubMesulam Center for Cognitive Neurology and Alzheimer's Disease, Northwestern University, Chicago, Illinois, USA.
B BoeveMayo Clinic, Rochester, Minnesota, USA.
A L BoxerMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
H RosenMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
K YaffeMemory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.
ARTFL/LEFFTDS Study
Mayo Clinic · USUniversity Memory and Aging Center · USUniversity of California, San Francisco · USUniversity of California, Los Angeles · USUniversity of Pennsylvania · USCase Western Reserve University · USUniversity of British Columbia · CAColumbia University · USHarvard University · USNorthwestern University · USThe University of Texas Southwestern Medical Center · USUniversity of Alabama at Birmingham · USUniversity of California San Diego · USUniversity of North Carolina at Chapel Hill · USUniversity of San Francisco · USUniversity of Toronto · CAUniversity of Washington · USWashington University in St. Louis · USWinnMed · US

Funding

Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Bradley F Boeve · 2019 to 2026
$120.9M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5M
Neuropathology CoreP30AG013854 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BIGIO, EILEEN H. · 1996 to 2020
$28.9M
TRANSCRIPTIONAL ATTENUATION OF THE TYPE I INTERFERON RESPONSE BY RHINOVIRUSP20RR015587 · NCRR · UNIVERSITY OF IDAHO · PI BOHACH, GREGORY A · 2000 to 2009
$19.0M
Understanding Environmental Contributions to Heterogeneity in bvFTD.P01AG066597 · NIA · UNIVERSITY OF PENNSYLVANIA · PI David John Irwin, Corey T McMillan · 2020 to 2026
$18.8M
Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9M
Multidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4M
Training - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4M
Neuroanatomical associations with the factor structure underlying neuropsychiatric symptoms in Alzheimer's diseaseR01AG062268 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUEY, EDWARD D · 2018 to 2022
$2.5M
Using RDoC Negative and Positive Valence Paradigms to Investigate the Mechanisms of Neuropsychiatric Symptoms (NPS) in Alzheimer's Disease and Related DementiasR01MH120794 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HUEY, EDWARD D · 2019 to 2023
$2.1M
Multimodal Imaging in Frontotemporal DegenerationK24AG045333 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSEN, HOWARD J · 2013 to 2023
$1.9M
Advancing Research and Treatment in Frontotemporal Lobar Degeneration L30AG057123Larry L. Hillblom Fellowship 2017-A-004-FELLongitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS; U01AG045390NCRR NIH HHS P20 RR015587NIA NIH HHS K23 AG058752NIA NIH HHS K23 AG061253NIA NIH HHS K24 AG045333NIA NIH HHS L30 AG057123NIA NIH HHS P01 AG019724NIA NIH HHS P01 AG066597NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG062421NIA NIH HHS R01 AG062268NIA NIH HHS T32 AG023481NIA NIH HHS U01 AG045390NIA NIH HHS U19 AG063911NIMH NIH HHS R01 MH120794NINDS NIH HHS U54 NS092089
6 · The paper itself

Abstract

introductionLeisure activities impact brain aging and may be prevention targets. We characterized how physical and cognitive activities relate to brain health for the first time in autosomal dominant frontotemporal lobar degeneration (FTLD).

methodsA total of 105 mutation carriers (C9orf72/MAPT/GRN) and 69 non-carriers reported current physical and cognitive activities at baseline, and completed longitudinal neurobehavioral assessments and brain magnetic resonance imaging (MRI) scans.

resultsGreater physical and cognitive activities were each associated with an estimated >55% slower clinical decline per year among dominant gene carriers. There was also an interaction between leisure activities and frontotemporal atrophy on cognition in mutation carriers. High-activity carriers with frontotemporal atrophy (-1 standard deviation/year) demonstrated >two-fold better cognitive performances per year compared to their less active peers with comparable atrophy rates. DISCUSSION: Active lifestyles were associated with less functional decline and moderated brain-to-behavior relationships longitudinally. More active carriers "outperformed" brain volume, commensurate with a cognitive reserve hypothesis. Lifestyle may confer clinical resilience, even in autosomal dominant FTLD.

Indexed as

ExerciseFrontotemporal Lobar DegenerationLeisure ActivitiesAgedAtrophyCognitionFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological Testscognitive activitycognitive reserveexercisefrontotemporal dementiaphysical activity

Identifiers

PMID31914227
PMCPMC6953618
OpenAlexW3000095436

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.