ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2020
Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort.
Registry-linked trialOpen access · greenAbstract readComparative Study
In one paragraph
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02372773 (Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects), which is not on this map. Cited by 29 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- The Differential Effects of Genetic Mutations in ALS and FTD Genes on Behavioural and Cognitive Changes: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Speech and language impairments in behavioral variant frontotemporal dementia: A systematic review.Neuroscience and biobehavioral reviews · 2021Pooled it
- Cardiovascular risk factors and the allostatic interoceptive network in dementia.Cardiovascular research · 2025Article
- Glial and neuronal cell-free DNA in plasma of sporadic bvFTD and late onset primary psychiatric disease patients.Scientific reports · 2025Article
- Longitudinal behavioral and neuropsychiatric changes and their MRI correlates in predementiaJournal of Alzheimer's disease : JAD · 2025Article
- Sex differences in clinical phenotypes of behavioral variant frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Amyotrophic lateral sclerosis caused by hexanucleotide repeat expansions in C9orf72: from genetics to therapeutics.The Lancet. Neurology · 2025Review
- Differentiating sporadic frontotemporal dementia from late-onset primary psychiatric disorders.Brain communications · 2025Article
- Serum neurofilament light is superior to glial fibrillary acidic protein to distinguish sporadic frontotemporal dementia from late-onset primary psychiatric disorders: a retrospective DIPPA-FTD study.BMJ neurology open · 2025Article
- Examining the relation between bilingualism and age of symptom onset in frontotemporal dementia.Bilingualism (Cambridge, England) · 2024Article
- Diagnostic accuracy of research criteria for prodromal frontotemporal dementia.Alzheimer's research & therapy · 2024Article
- Rationale and Design of the "DIagnostic and Prognostic Precision Algorithm for behavioral variant Frontotemporal Dementia" (DIPPA-FTD) Study: A Study Aiming to Distinguish Early Stage Sporadic FTD from Late-Onset Primary Psychiatric Disorders.Journal of Alzheimer's disease : JAD · 2024Article
- Anterior cingulate sulcation is associated with onset and survival in frontotemporal dementia.Brain communications · 2023Article
- Neurocognitive patterns across genetic levels in behavioral variant frontotemporal dementia: a multiple single cases study.BMC neurology · 2022Article
- The contribution of behavioral features to caregiver burden in FTLD spectrum disorders.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Preclinical evaluation of WVE-004, aninvestigational stereopure oligonucleotide forthe treatment ofMolecular therapy. Nucleic acids · 2022Article
- Proposed research criteria for prodromal behavioural variant frontotemporal dementia.Brain : a journal of neurology · 2022Article
- Comparative diagnosis interest of NfL and pNfH in CSF and plasma in a context of FTD-ALS spectrum.Journal of neurology · 2022Article
- Differences and similarities between familial and sporadic frontotemporal dementia: An Italian single-center cohort study.Alzheimer's & dementia (New York, N. Y.) · 2022Article
- Recognition memory and divergent cognitive profiles in prodromal genetic frontotemporal dementia.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
78 authors at 20 institutions in 3 countries.
Hilary W HeuerUniversity of California, San Francisco, San Francisco, California.
P WangUniversity of California, San Francisco, San Francisco, California.
K RascovskyUniversity of Pennsylvania, Philadelphia, Pennsylvania.
A WolfUniversity of California, San Francisco, San Francisco, California.
B ApplebyCase Western Reserve University, Cleveland, Ohio.
J BoveUniversity of Pennsylvania, Philadelphia, Pennsylvania.
Y BordelonUniversity of California, Los Angeles, Los Angeles, California.
P BrannellyTau Consortium, Rainwater Charitable Foundation, Fort Worth, Texas.
D E BrushaberMayo Clinic, Rochester, Minnesota.
C CasoU Washington, Seattle, Washington.
G CoppolaUniversity of California, Los Angeles, Los Angeles, California.
B DickersonHarvard University/MGH, Boston, Massachusetts.
S DickinsonAssociation for Frontotemporal Degeneration, Radnor, Pennsylvania.
K Domoto-ReillyU Washington, Seattle, Washington.
K FaberNational Centralized Repository for Alzheimer's Disease and Related Disorders (NCRAD), Indiana University, Indianapolis, Indiana.
J FerrallUniversity of North Carolina, Chapel Hill, North Carolina.
J FieldsMayo Clinic, Rochester, Minnesota.
A FishmanJohns Hopkins University, Baltimore, Maryland.
J FongUniversity of California, San Francisco, San Francisco, California.
T ForoudNational Centralized Repository for Alzheimer's Disease and Related Disorders (NCRAD), Indiana University, Indianapolis, Indiana.
L K ForsbergMayo Clinic, Rochester, Minnesota.
D GearhartMayo Clinic, Rochester, Minnesota.
B GhazanfariUniversity of Toronto, Toronto, Ontario, Canada.
N GhoshalWashington University, St. Louis, Missouri.
J GoldmanColumbia University, New York, New York.
J Graff-RadfordMayo Clinic, Rochester, Minnesota.
N Graff-RadfordMayo Clinic, Jacksonville, Florida.
I GrantNorthwestern University, Chicago, Illinois.
M GrossmanUniversity of Pennsylvania, Philadelphia, Pennsylvania.
D HaleyMayo Clinic, Jacksonville, Florida.
G-Y HsiungUniversity of British Columbia, Vancouver, British Columbia, Canada.
E HueyColumbia University, New York, New York.
D IrwinUniversity of Pennsylvania, Philadelphia, Pennsylvania.
D JonesMayo Clinic, Rochester, Minnesota.
K KantarciMayo Clinic, Rochester, Minnesota.
A KarydasUniversity of California, San Francisco, San Francisco, California.
D KauferUniversity of North Carolina, Chapel Hill, North Carolina.
D KerwinThe University of Texas, Southwestern Medical Center at Dallas, Dallas, Texas.
D KnopmanMayo Clinic, Rochester, Minnesota.
J KornakUniversity of California, San Francisco, San Francisco, California.
J H KramerUniversity of California, San Francisco, San Francisco, California.
R KraftMayo Clinic, Rochester, Minnesota.
W K KremersMayo Clinic, Rochester, Minnesota.
W KukullNational Alzheimer Coordinating Center (NACC), University of Washington, Seattle, Washington.
I LitvanUniversity of California, San Diego, San Diego, California.
P LjubenkovUniversity of California, San Francisco, San Francisco, California.
I R MackenzieUniversity of British Columbia, Vancouver, British Columbia, Canada.
M MaldonadoUniversity of California, Los Angeles, Los Angeles, California.
M ManoochehriColumbia University, New York, New York.
S McGinnisHarvard University/MGH, Boston, Massachusetts.
E McKinleyUniversity of Alabama at Birmingham, Birmingham, Alabama.
M F MendezUniversity of California, Los Angeles, Los Angeles, California.
B L MillerUniversity of California, San Francisco, San Francisco, California.
C OnyikeJohns Hopkins University, Baltimore, Maryland.
A PantelyatJohns Hopkins University, Baltimore, Maryland.
R PearlmanBluefield Project, San Francisco, California.
L PetrucelliMayo Clinic, Jacksonville, Florida.
M PotterNational Centralized Repository for Alzheimer's Disease and Related Disorders (NCRAD), Indiana University, Indianapolis, Indiana.
R RademakersMayo Clinic, Jacksonville, Florida.
E M RamosUniversity of California, Los Angeles, Los Angeles, California.
K P RankinUniversity of California, San Francisco, San Francisco, California.
E D RobersonUniversity of Alabama at Birmingham, Birmingham, Alabama.
E RogalskiNorthwestern University, Chicago, Illinois.
P SengdyUniversity of British Columbia, Vancouver, British Columbia, Canada.
L ShawUniversity of Pennsylvania, Philadelphia, Pennsylvania.
J SyrjanenMayo Clinic, Rochester, Minnesota.
M C TartagliaUniversity of Toronto, Toronto, Ontario, Canada.
N TattonAssociation for Frontotemporal Degeneration, Radnor, Pennsylvania.
J TaylorUniversity of California, San Francisco, San Francisco, California.
A TogaLaboratory of Neuroimaging (LONI), USC, Los Angeles, California.
J TrojanowskiCase Western Reserve University, Cleveland, Ohio.
S WeintraubNorthwestern University, Chicago, Illinois.
B WongHarvard University/MGH, Boston, Massachusetts.
Z WszolekMayo Clinic, Jacksonville, Florida.
B F BoeveMayo Clinic, Rochester, Minnesota.
H J RosenUniversity of California, San Francisco, San Francisco, California.
A L BoxerUniversity of California, San Francisco, San Francisco, California.
ARTFL and LEFFTDS consortia
University of California, San Francisco · USMayo Clinic · USUniversity of California, Los Angeles · USUniversity of Pennsylvania · USColumbia University · USJohns Hopkins University · USMayo Clinic in Florida · USNorthwestern University · USUniversity of British Columbia · CAAlzheimer’s Disease Neuroimaging Initiative · USAssociation for Frontotemporal Degeneration · USCase Western Reserve University · USHarvard University Press · USUniversity of Alabama at Birmingham · USUniversity of North Carolina at Chapel Hill · USUniversity of Toronto · CAUniversity of Washington Applied Physics Laboratory · USWinnMed · USBluefield College · USCognitive Neuroimaging Lab · FR
Funding
Technology and Remote Assessment CoreU19AG063911 · NIA · MAYO CLINIC ROCHESTER · PI Bradley F Boeve · 2019 to 2026
$120.9MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MNATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MSatellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3MResearch Education ComponentP30AG062421 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Christine S Ritchie · 2019 to 2026
$36.5MNeuropathology CoreP30AG013854 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BIGIO, EILEEN H. · 1996 to 2020
$28.9MUnderstanding Environmental Contributions to Heterogeneity in bvFTD.P01AG066597 · NIA · UNIVERSITY OF PENNSYLVANIA · PI David John Irwin, Corey T McMillan · 2020 to 2026
$18.8MThe Four Repeat Tauopathy Neuroimaging InitiativeR01AG038791 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2010 to 2020
$18.1MLongitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)U01AG045390 · NIA · MAYO CLINIC ROCHESTER · PI BOEVE, BRADLEY F, ROSEN, HOWARD J · 2014 to 2018
$16.9MMultidisciplinary Research Fellowship in Alzheimer’s disease and Related DementiasT32AG023481 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BRUCE L MILLER, HOWARD J ROSEN · 2005 to 2026
$7.4MTraining - The Frontotemporal Lobar Degeneration Clinical Research ConsortiumU54NS092089 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BOXER, ADAM L. · 2014 to 2018
$6.4MNIA NIH HHS K24 AG045333NIA NIH HHS P01 AG019724NIA NIH HHS P01 AG066597NIA NIH HHS P30 AG013854NIA NIH HHS P30 AG062421NIA NIH HHS P50 AG008702NIA NIH HHS R01 AG062268NIA NIH HHS T32 AG023481NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG045390NIA NIH HHS U19 AG063911NIA NIH HHS U24 AG021886NIH HHS U01 AG016976NIH HHS U01 AG045390NIH HHS U24 AG021886NIH HHS U54 NS092089NIMH NIH HHS R01 MH120794NINDS NIH HHS U54 NS092089
Abstract
introductionBehavioral variant frontotemporal dementia (bvFTD) may present sporadically or due to an autosomal dominant mutation. Characterization of both forms will improve understanding of the generalizability of assessments and treatments.
methodsA total of 135 sporadic (s-bvFTD; mean age 63.3 years; 34% female) and 99 familial (f-bvFTD; mean age 59.9; 48% female) bvFTD participants were identified. f-bvFTD cases included 43 with known or presumed chromosome 9 open reading frame 72 (C9orf72) gene expansions, 28 with known or presumed microtubule-associated protein tau (MAPT) mutations, 14 with known progranulin (GRN) mutations, and 14 with a strong family history of FTD but no identified mutation.
resultsParticipants with f-bvFTD were younger and had earlier age at onset. s-bvFTD had higher total Neuropsychiatric Inventory Questionnaire (NPI-Q) scores due to more frequent endorsement of depression and irritability. DISCUSSION: f-bvFTD and s-bvFTD cases are clinically similar, suggesting the generalizability of novel biomarkers, therapies, and clinical tools developed in either form to the other.
Indexed as
Frontotemporal DementiaGenetic Predisposition to DiseaseAgedAge FactorsBrainC9orf72 ProteinFemaleHumansMaleMiddle AgedMutationNeuropsychological TestsNorth AmericaProgranulinstau ProteinsC9orf72 ProteinC9orf72 protein, humanGRN protein, humanMAPT protein, humanProgranulinstau ProteinsbvFTDC9orf72clinical trialsfrontotemporal dementiageneticsGRNMAPT
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
NCT02372773ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.