ArticlePLoS computational biology2020
The origin of biological homochirality along with the origin of life.
Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Exonuclease Ribozyme Encoded in a Circular Genome: On the Initiation of the RNA World.Life (Basel, Switzerland) · 2026Article
- Single-Crystal NMR forACS physical chemistry Au · 2026Article
- Spontaneous Emergence of Homochiral Suspensions from Racemic Solutions via Stochastic Nucleation.Journal of the American Chemical Society · 2025Article
- Chirality-Promoted Chemical Ligation and Reverse Transcription ofJournal of the American Chemical Society · 2025Article
- A Metric for the Entropic Purpose of a System.Entropy (Basel, Switzerland) · 2025Article
- Functional biosynthetic stereodivergence in a gene cluster via a dihydrosydnone N-oxide.Communications chemistry · 2024Article
- The First Reciprocal Activities of Chiral Peptide Pharmaceuticals: Thymogen and Thymodepressin, as Examples.International journal of molecular sciences · 2024Review
- Exact and Ubiquitous Condition for Solid-State Deracemization in Vitro and in Nature.Journal of the American Chemical Society · 2024Article
- Circular at the very beginning: on the initial genomes in the RNA world.RNA biology · 2024Article
- Conditions for the origin of homochirality in primordial catalytic reaction networks.Scientific reports · 2023Article
- Prebiotic Synthesis of ATP: A Terrestrial Volcanism-Dependent Pathway.Life (Basel, Switzerland) · 2023Article
- Towards an RNA/Peptides World by the Direct RNA Template Mechanism: The Emergence of Membrane-Stabilizing Peptides in RNA-Based Protocells.Life (Basel, Switzerland) · 2023Article
- In Planta, In Vitro and In Silico Studies of ChiralInternational journal of molecular sciences · 2022Article
- Arrow of Time, Entropy, and Protein Folding: Holistic View on Biochirality.International journal of molecular sciences · 2022Review
- Effects of shape and solute-solvent compatibility on the efficacy of chirality transfer: Nanoshapes in nematics.Science advances · 2022Article
- Advances in TherapeuticGenes · 2021Review
- The automatic parameter-exploration with a machine-learning-like approach: Powering the evolutionary modeling on the origin of life.PLoS computational biology · 2021Article
- Recent developments in the chiroptical properties of chiral plasmonic gold nanostructures: bioanalytical applications.Mikrochimica acta · 2021Review
- Determining the Diastereoselectivity of the Formation of Dipeptidonucleotides by NMR Spectroscopy.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Symmetry breaking meets multisite modification.eLife · 2021Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How homochirality concerning biopolymers (DNA/RNA/proteins) could have originally occurred (i.e., arisen from a non-life chemical world, which tended to be chirality-symmetric) is a long-standing scientific puzzle. For many years, people have focused on exploring plausible physic-chemical mechanisms that may have led to prebiotic environments biased to one chiral type of monomers (e.g., D-nucleotides against L-nucleotides; L-amino-acids against D-amino-acids)-which should have then assembled into corresponding polymers with homochirality, but as yet have achieved no convincing advance. Here we show, by computer simulation-with a model based on the RNA world scenario, that the biased-chirality may have been established at polymer level instead, just deriving from a racemic mixture of monomers (i.e., equally with the two chiral types). In other words, the results suggest that the homochirality may have originated along with the advent of biopolymers during the origin of life, rather than somehow at the level of monomers before the origin of life.
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