Evidence map›Paper›PMID 31913999›Full record

ArticleJournal of acquired immune deficiency syndromes (1999)2020

HIV Seroconversion and Types of Relationships Among Men Who Have Sex With Men: A Cohort Study in China.

Xiaoming Sun, Chunyan Wang, Kun Zhao, Lifen Zhang, Menglong Li, Dianqin Sun, Wen Shu, Yuhua Ruan, Jinyan Zhang, Sten H Vermund and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of acquired immune deficiency syndromes (1999), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Xiaoming SunDepartment of Child, Adolescent Health and Maternal Health, School of Public Health, Capital Medical University, Beijing, China.
Chunyan WangDepartment of Pathology, Daxing District People's Hospital, Beijing, China.
Kun ZhaoDepartment of Child, Adolescent Health and Maternal Health, School of Public Health, Capital Medical University, Beijing, China.
Lifen ZhangProgram Management Office, Chaoyang Center for Disease Control and Prevention, Beijing, China.
Menglong LiDepartment of Child, Adolescent Health and Maternal Health, School of Public Health, Capital Medical University, Beijing, China.
Dianqin SunDepartment of Child, Adolescent Health and Maternal Health, School of Public Health, Capital Medical University, Beijing, China.
Wen ShuDepartment of Child, Adolescent Health and Maternal Health, School of Public Health, Capital Medical University, Beijing, China.
Yuhua RuanState Key Laboratory for Infectious Disease Prevention and Control, Chinese Center for Disease Control and Prevention, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Beijing, China; and.
Jinyan ZhangProgram Management Office, Chaoyang Center for Disease Control and Prevention, Beijing, China.
Sten H VermundYale School of Public Health, Yale University, New Haven, Connecticut.
Dongliang LiProgram Management Office, Chaoyang Center for Disease Control and Prevention, Beijing, China.
Yifei HuDepartment of Child, Adolescent Health and Maternal Health, School of Public Health, Capital Medical University, Beijing, China.
Capital Medical University · CNBeijing Center for Disease Prevention and Control · CNChinese Center For Disease Control and Prevention · CNShaoxing People's Hospital · CNYale University · US

Funding

Using Coincidence Analysis to Investigate Factors Affecting PrEP Initiation and Continuation in Southern ending the Epidemic CountiesP30MH062294 · NIMH · YALE UNIVERSITY · PI John Edward Pachankis · 2001 to 2026
$48.5M
NIMH NIH HHS P30 MH062294
6 · The paper itself

Abstract

backgroundThe role of partner types in modifying HIV seroconversion risk among men who have sex with men (MSM) is complex. We sought to understand the role of regular sexual partners and risky sexual behavior in contributing to incident HIV infection among MSM.

methodsFrom July 2011 to August 2017, we recruited HIV-negative men who reported having anal or oral homosexual encounters in the past 6 months and they were followed up every 3 months for 2 visits. We collected sociodemographic and behavioral characteristics by a self-administrated questionnaire. HIV status was confirmed by a sequential rapid test and confirmatory test. We used multivariable Cox regression to identify risk factors and interaction models to evaluate the relative excess risk between relevant variables.

resultsAmong 1218 participants, the HIV seroconversion rate was 3.66/100 person-years. HIV seroconversion was associated with lower educational attainment [adjusted hazards ratio (aHR)] = 1.73, 95% CI: 1.06 to 2.81), having had penetrative sex with male before age of 18 years (aHR = 2.44, 95% CI: 1.20 to 4.99), not using condoms in the last sexual encounter (aHR = 2.19, 95% CI: 1.29 to 3.71), and having regular but not committed partners (aHR = 3.33, 95% CI: 1.77 to 6.93). Among 890 (73%) of men reported having regular partners, HIV seroconversion was more frequent in men whose stable partners were not committed as boyfriends (aHR = 3.31, 95% CI: 1.73 to 6.36) and in men having unprotected anal sex (aHR = 2.61, 95% CI: 1.42 to 4.80). Interaction between these 2 factors was observed (relative excess risk of interaction = 4.53).

conclusionsIncidence among MSM in China was high; unprotected sex with steady but not committed partners was associated with increased seroconversion risk. It is imperative to expand safer sex education and training for MSM to reduce unsafe sexual behaviors, including awareness that casual partners are not the only source of infection.

Indexed as

Homosexuality, MaleChinaCohort StudiesHIV InfectionsHIV SeropositivityHumansMaleRisk FactorsSafe SexUnsafe Sex

Identifiers

PMID31913999
PMCPMC7055498
OpenAlexW3000412586

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.