Evidence map›Paper›PMID 31913756›Full record

ArticleMolecular biology of the cell2020

Viral protein X unlocks the nuclear pore complex through a human Nup153-dependent pathway to promote nuclear translocation of the lentiviral genome.

Satya Prakash Singh, Sebastian Raja, Sundarasamy Mahalingam

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular biology of the cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 58% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Current view on HIV-2 - epidemiology, diagnosis and treatment.Central European journal of public health · 2025
    Review
  3. Transcriptomic Analysis Reveals Key Pathways Influenced by HIV-2 Vpx.International journal of molecular sciences · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Satya Prakash SinghLaboratory of Molecular Cell Biology, Indian Institute of Technology-Madras, Chennai 600 036, India.
Sebastian RajaLaboratory of Molecular Cell Biology, Indian Institute of Technology-Madras, Chennai 600 036, India.
Sundarasamy MahalingamLaboratory of Molecular Cell Biology, Indian Institute of Technology-Madras, Chennai 600 036, India.
Indian Institute of Technology Madras · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Simian immunodeficiency virus (SIV) and human immunodeficiency virus 2 (HIV-2) display unique ability to infect nondividing target cells. Viral protein X (Vpx) of HIV-2/SIV is known to be involved in the nuclear import of viral genome in nondividing cells, but the mechanism remains poorly understood. In the present investigation for the first time we provide evidence that Vpx of SIV

Indexed as

Genome, ViralActive Transport, Cell NucleusAnimalsGene Expression RegulationHaplorhiniHEK293 CellsHeLa CellsHIV-2Host-Pathogen InteractionsHumansMitogen-Activated Protein Kinase 1Nuclear PoreNuclear Pore Complex ProteinsPhosphorylationSignal TransductionSimian Immunodeficiency VirusMAPK1 protein, humanMitogen-Activated Protein Kinase 1Nuclear Pore Complex ProteinsNUP153 protein, humanViral Regulatory and Accessory ProteinsVPX protein, Human immunodeficiency virus 2VPX protein, Simian immunodeficiency virus

Identifiers

PMID31913756
PMCPMC7183765
OpenAlexW2999901837

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.