Evidence map›Paper›PMID 31913693›Full record

ArticleAmerican journal of physiology. Cell physiology2020

High-mobility group box-1 increases epithelial sodium channel activity and inflammation via the receptor for advanced glycation end products.

Garett J Grant, Theodore G Liou, Robert Paine, My N Helms

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Cell physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Acute lung injury: a view from the perspective of necroptosis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024
    Review
  2. The Epithelial Sodium Channel-An Underestimated Drug Target.International journal of molecular sciences · 2023
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Garett J GrantPulmonary Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah.
Theodore G LiouPulmonary Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah.ORCID 0000-0003-0121-4847
Robert PainePulmonary Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah.ORCID 0000-0002-4511-4437
My N HelmsPulmonary Division, Department of Internal Medicine, University of Utah, Salt Lake City, Utah.
University of Utah · US

Funding

Oxidized glutathione regulation of epithelial sodium channels in newborn lung injuryR01HL137033 · NHLBI · UNIVERSITY OF UTAH · PI HELMS, MY N. · 2018 to 2021
$1.5M
Explanatory models of CF Survival, Infection and Intermediate Clinical OutcomesR01HL125520 · NHLBI · UNIVERSITY OF UTAH · PI LIOU, THEODORE GEH-LU · 2015 to 2018
$1.4M
NHLBI NIH HHS R01 HL125520NHLBI NIH HHS R01 HL137033
6 · The paper itself

Abstract

Cystic fibrosis (CF) lung disease persists and remains life-limiting for many patients. Elevated high-mobility group box-1 protein (HMGB-1) levels and epithelial sodium channel hyperactivity (ENaC) are hallmark features of the CF lung. The objective of this study was to better understand the pathogenic role of HMGB-1 signaling and ENaC in CF airway cells. We hypothesize that HMGB-1 links airway inflammation [via signaling to the receptor for advanced glycation end products (RAGE)] and airway surface liquid dehydration (via upregulation of ENaC) in the CF lung. We calculated equivalent short-current (

Indexed as

AnimalsCells, CulturedEpithelial Sodium ChannelsFemaleHMGB1 ProteinHumansInflammationInflammation MediatorsMaleMiceMice, Inbred C57BLMice, TransgenicReceptor for Advanced Glycation End ProductsRespiratory MucosaAGER protein, humanEpithelial Sodium ChannelsHMGB1 ProteinHMGB1 protein, humanInflammation MediatorsReceptor for Advanced Glycation End Productsairway inflammationcystic fibrosiscytokinesENaCHMGB-1RAGE

Identifiers

PMID31913693
PMCPMC7099525
OpenAlexW3000495298

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.