Evidence map›Paper›PMID 31913654›Full record

ArticleAmerican journal of physiology. Lung cellular and molecular physiology2020

Upregulation of airway smooth muscle calcium-sensing receptor by low-molecular-weight hyaluronan.

Ahmed Lazrak, Zhihong Yu, Stephen Doran, Ming-Yuan Jian, Judy Creighton, Mandy Laube, Stavros Garantziotis, Y S Prakash, Sadis Matalon

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Lung cellular and molecular physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.7field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Hemopexin reverses activation of lung eIF2α and decreases mitochondrial injury in chlorine-exposed mice.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  4. Article
  5. Low molecular weight hyaluronan inhibits lung epithelial ion channels by activating the calcium-sensing receptor.Matrix biology : journal of the International Society for Matrix Biology · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Hyaluronan and halogen-induced airway hyperresponsiveness and lung injury.Annals of the New York Academy of Sciences · 2020
    Review
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Ahmed LazrakDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine & Pulmonary Injury Repair Center, University of Alabama at Birmingham, Birmingham, Alabama.
Zhihong YuDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine & Pulmonary Injury Repair Center, University of Alabama at Birmingham, Birmingham, Alabama.
Stephen DoranDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine & Pulmonary Injury Repair Center, University of Alabama at Birmingham, Birmingham, Alabama.
Ming-Yuan JianDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine & Pulmonary Injury Repair Center, University of Alabama at Birmingham, Birmingham, Alabama.
Judy CreightonDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine & Pulmonary Injury Repair Center, University of Alabama at Birmingham, Birmingham, Alabama.
Mandy LaubeDepartment of Pediatrics, Division of Neonatology, Leipzig University, Leipzig, Germany.
Stavros GarantziotisMatrix Biology Group, Immunity, Inflammation, and Disease Laboratory, National Institutes of Health/National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.ORCID 0000-0003-4007-375X
Y S PrakashDepartment of Physiology and Biomedical Engineering and Anesthesiology, Mayo Clinic Alix School of Medicine and Science, Rochester, Minnesota.ORCID 0000-0002-2968-224X
Sadis MatalonDepartment of Anesthesiology and Perioperative Medicine, Division of Molecular and Translational Biomedicine & Pulmonary Injury Repair Center, University of Alabama at Birmingham, Birmingham, Alabama.
University of Alabama at Birmingham · USLeipzig University · DEMayo Clinic · USNational Institutes of Health · US

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Brian R. Davis · 2007 to 2026
$23.0M
The Role of Hyaluronan And Inter-Alpha-Trypsin Inhibitor in Tissue InjuryZIAES102605 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI GARANTZIOTIS, STAVROS · 2009 to 2025
$22.6M
NEURAL REGULATION OF AIRWAYS DURING POSTNATAL MATURATIONR01HL056470 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S. · 1996 to 2025
$10.5M
Bromine Inhalation Induced Lung Injury: Novel Mechanisms and Treatment StrategiesU01ES026458 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MATALON, SADIS · 2015 to 2019
$3.9M
CIALIS® reverses halogen induced injury to pregnant animals and their offspringU01ES027697 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JILLING, TAMAS SANDOR, MATALON, SADIS · 2016 to 2020
$3.7M
Understanding CPAP Effects in the Developing AirwayR01HL138402 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI MACFARLANE, PETER · 2017 to 2020
$2.5M
Intramural NIH HHS ZIA ES102605NHLBI NIH HHS R01 HL056470NHLBI NIH HHS R01 HL138402NIDDK NIH HHS P30 DK072482NIEHS NIH HHS U01 ES026458NIEHS NIH HHS U01 ES027697
6 · The paper itself

Abstract

We investigated the mechanisms involved in the development of airway hyperresponsiveness (AHR) following exposure of mice to halogens. Male mice (C57BL/6; 20-25 g) exposed to either bromine (Br

Indexed as

AnimalsBromineCalciumCalcium Channel BlockersCells, CulturedChloridesHumansHyaluronic AcidMaleMiceMice, Inbred C57BLMolecular WeightMuscle, SmoothReceptors, Calcium-SensingRespiratory HypersensitivityViscosupplementsBromineCalciumCalcium Channel BlockersChloridesHyaluronic AcidReceptors, Calcium-SensingViscosupplementsairway hyperresponsivenesscalcium-sensing receptordiltiazemhalogenshuman airway smooth muscle cellsmembrane potentialnifedipine

Identifiers

PMID31913654
PMCPMC7099432
OpenAlexW3000399272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.