ArticleScientific reports2020
Characteristics of induced mutations in offspring derived from irradiated mouse spermatogonia and mature oocytes.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
- Overview and future studies of potential hereditary effects of parental exposure to atomic bomb radiation on their offspring.Carcinogenesis · 2025Review
- Genomic landscape of radiation-induced somatic mutations in a normal cell.Carcinogenesis · 2025Review
- DNA polymerase β suppresses somatic indels at CpG dinucleotides in developing cortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Trans-Scale Insights into Variability in Radiation Cancer Risk Across Tissues, Individuals, and Species.Biology · 2025Review
- Evidence for a transgenerational mutational signature from ionizing radiation exposure in humans.Scientific reports · 2025Article
- Establishment and activity of the planning and acting network for low dose radiation research in Japan (PLANET): 2016-2023.Journal of radiation research · 2024Article
- Spectra and characteristics of somatic mutations induced by ionizing radiation in hematopoietic stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Parental chest computerized tomography examination before IVF/ICSI has no impact on pregnancy and neonatal outcomes: a cohort study of 2680 fresh transfer cycles.BMC pregnancy and childbirth · 2022Article
- Massive expansion of multiple clones in the mouse hematopoietic system long after whole-body X-irradiation.Scientific reports · 2022Article
- Article
- Early embryonic mutations reveal dynamics of somatic and germ cell lineages in mice.Genome research · 2022Article
- Increased Frequency of Copy Number Variations Revealed by Array Comparative Genomic Hybridization in the Offspring of Male Mice Exposed to Low Dose-Rate Ionizing Radiation.International journal of molecular sciences · 2021Article
- Ethical, legal and social implications of human genome studies in radiation research: a workshop report for studies on atomic bomb survivors at the Radiation Effects Research Foundation.Journal of radiation research · 2021Article
- Effect of sampling time on somatic and germ cell mutations induced by acrylamide in gpt delta mice.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Article
- Article
- Inferring evolutionary dynamics of mutation rates through the lens of mutation spectrum variation.Current opinion in genetics & development · 2020Review
- Effects of paternal ionizing radiation exposure on fertility and offspring's health.Reproductive medicine and biologyArticle
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The exposure of germ cells to radiation introduces mutations in the genomes of offspring, and a previous whole-genome sequencing study indicated that the irradiation of mouse sperm induces insertions/deletions (indels) and multisite mutations (clustered single nucleotide variants and indels). However, the current knowledge on the mutation spectra is limited, and the effects of radiation exposure on germ cells at stages other than the sperm stage remain unknown. Here, we performed whole-genome sequencing experiments to investigate the exposure of spermatogonia and mature oocytes. We compared de novo mutations in a total of 24 F1 mice conceived before and after the irradiation of their parents. The results indicated that radiation exposure, 4 Gy of gamma rays, induced 9.6 indels and 2.5 multisite mutations in spermatogonia and 4.7 indels and 3.1 multisite mutations in mature oocytes in the autosomal regions of each F1 individual. Notably, we found two types of deletions, namely, small deletions (mainly 1~12 nucleotides) in non-repeat sequences, many of which showed microhomology at the breakpoint junction, and single-nucleotide deletions in mononucleotide repeat sequences. The results suggest that these deletions and multisite mutations could be a typical signature of mutations induced by parental irradiation in mammals.
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