ArticleNature communications2020
Implementing digital computing with DNA-based switching circuits.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
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Who cites it
56 citing papers in PubMed.
- Spatially Encoded Protocell Network for Non-Cascaded Parallel Biocomputation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Soft Hardware, Flowing Software: Reconfigurable Microfluidics for Adaptable Chemical Computation.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Intracellular logic computing with DNA tetrahedron processors enables precision cancer theranostics.Signal transduction and targeted therapy · 2026Article
- A general and scalable DNA nano-chip with a fully localized architecture enables biocomputing in living cells and precisely induces cell apoptosis.Chemical science · 2026Article
- Reset-free DNA logic circuits for real-time input processing and memory.Science advances · 2026Article
- Enzymatic colorimetric encoding-based digital medicine for pancreatic cancer diagnosis.Nature communications · 2026Article
- Concept, development and applications of DNA computation.Fundamental research · 2026Review
- Single DNA hairpin nanowire based on self-hybridization chain reaction for sensitive ATP detection.Science and technology of advanced materials · 2026Article
- Deep convolutional and fully-connected DNA neural networks.Nature communications · 2025Article
- Nick-and-Digest Strategy for Programmable Circular ssDNA Production and Scalable DNA Origami Assembly.JACS Au · 2025Article
- Multiplexed and high-bandwidth DNA computing circuits with superresolution DNA origami displays.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Intelligent molecular logic computing toolkits: nucleic acid-based construction, functionality, and enhanced biosensing applications.Chemical science · 2025Review
- DNA computing function switching by programming base stacking interactions with minimal molecular architecture changes.Nature communications · 2025Article
- Programmable DNA-Based Molecular Neural Network Biocomputing Circuits for Solving Partial Differential Equations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Designing a DNA synchronizer for compact single-rail DNA logic circuits.Science advances · 2025Article
- Article
- Optimal approximate computation of Euclidean distance in spiking neural P systems framework.Scientific reports · 2025Article
- Implementing complex nucleic acid circuits in living cells.Science advances · 2025Article
- Nucleic Acid Framework-Enabled Spatial Organization for Biological Applications.Chem & bio engineering · 2025Review
- A Localized Scalable DNA Logic Circuit System Based on the DNA Origami Surface.International journal of molecular sciences · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA strand displacement reactions (SDRs) provide a set of intelligent toolboxes for developing molecular computation. Whereas SDR-based logic gate circuits have achieved a high level of complexity, the scale-up for practical achievable computational tasks remains a hurdle. Switching circuits that were originally proposed by Shannon in 1938 and nowadays widely used in telecommunication represent an alternative and efficient means to realize fast-speed and high-bandwidth communication. Here we develop SDR-based DNA switching circuits (DSCs) for implementing digital computing. Using a routing strategy on a programmable DNA switch canvas, we show that arbitrary Boolean functions can be represented by DSCs and implemented with molecular switches with high computing speed. We further demonstrate the implementation of full-adder and square-rooting functions using DSCs, which only uses down to 1/4 DNA strands as compared with a dual-rail logic expression-based design. We expect that DSCs provide a design paradigm for digital computation with biomolecules.
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