ArticleScientific reports2020
Vitamin D supplementation does not prevent the recurrence of Graves' disease.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- The Role of Vitamin D in Autoimmune Thyroid Diseases: From Immunomodulation to Clinical Implications.Nutrients · 2026Review
- Vitamin D and gut microbiota in thyroid diseases: mechanisms and therapeutic potential.Frontiers in immunology · 2026Review
- Vitamin D in Endocrine Disorders: A Broad Overview of Evidence in Musculoskeletal, Thyroid, Parathyroid, and Reproductive Disorders.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Shared Immunopathogenic Mechanisms in Chronic Spontaneous Urticaria, Vitiligo, and Hashimoto's Thyroiditis: The Role of Oxidative Stress and Vitamin D.Life (Basel, Switzerland) · 2025Review
- The Essential Role of Vitamin D in Pediatric Health: Implications for Oropharyngeal Infections and Neutropenia-Associated Vulnerability.Children (Basel, Switzerland) · 2025Article
- Genetic evidence of the causal relationship between serum micronutrients and Graves' disease: A Mendelian randomization and cross-sectional observational study.Asia Pacific journal of clinical nutrition · 2025Observational
- Effects of vitamin D replacement combined with Graves' disease therapy: a retrospective cohort study.Turkish journal of medical sciences · 2025Article
- Case Report: Resolution of complete heart block following vitamin D supplementation in a child with Graves disease.Frontiers in endocrinology · 2025Article
- Genome-wide association study of maternal plasma metabolites during pregnancy.Cell genomics · 2024Article
- Vitamin D: An Essential Nutrient in the Dual Relationship between Autoimmune Thyroid Diseases and Celiac Disease-A Comprehensive Review.Nutrients · 2024Review
- T-cell exhaustion-related genes in Graves' disease: a comprehensive genome mapping analysis.Frontiers in endocrinology · 2024Article
- Vitamin D and bone metabolism in Graves' disease: a prospective study.Journal of endocrinological investigation · 2023Article
- A Mendelian randomization study of the effect of serum 25-hydroxyvitamin D levels on autoimmune thyroid disease.Frontiers in immunology · 2023Article
- The correlation between vitamin D and levels of IFN-γ, NF-κB, thyroid antibodies in down syndrome: study in Indonesian children.Acta bio-medica : Atenei Parmensis · 2022Article
- Associations between second to fourth digit ratio, cortisol, vitamin D, and body composition among Polish children.Scientific reports · 2021Article
- Vitamin D, Thyroid Hormones and Cardiovascular Risk: Exploring the Components of This Novel Disease Triangle.Frontiers in physiology · 2021Review
- Immunomodulatory Function of Vitamin D and Its Role in Autoimmune Thyroid Disease.Frontiers in immunology · 2021Review
- Review
- Immunomodulatory Effects of Vitamin D in Thyroid Diseases.Nutrients · 2020Review
- Pathophysiological Role and Therapeutic Implications of Vitamin D in Autoimmunity: Focus on Chronic Autoimmune Diseases.Nutrients · 2020Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent literature has reported a higher prevalence of vitamin D deficiency among people with Graves' disease. No study has examined the effect of vitamin D supplementation on the clinical outcomes of Graves' disease. We aimed to evaluate whether daily vitamin D supplementation reduces Graves' disease recurrence. We enrolled 210 subjects with Graves' disease and vitamin D deficiency and followed them for at least one year after anti-thyroid drug (ATD) discontinuation. Among 210 individuals, 60 (29%) were amenable to taking vitamin D supplements, resulting in sufficient vitamin D levels (from 10.6 to 25.7 ng/mL), whereas the mean vitamin D level was 11.6 ng/mL in the 150 patients who did not take vitamin D supplements. The recurrence rate was similar in both groups (38% vs. 49%, P = 0.086). However, recurrence occurred earlier in the latter group (7 months vs. 5 months, P = 0.016). In the multivariate analysis, vitamin D levels and TSH-binding inhibitory immunoglobulin (TBII) titers at ATD discontinuation remained significant factors for recurrence. Vitamin D levels and TBII titers at ATD discontinuation exhibited a weak negative correlation (R = -0.143, P = 0.041). Vitamin D supplementation might have a protective effect against Graves' disease recurrence with a borderline significant recurrence rate reduction.
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