Evidence map›Paper›PMID 31913278›Full record

ArticleNature communications2020

Differential expansion of T central memory precursor and effector subsets is regulated by division speed.

Lorenz Kretschmer, Michael Flossdorf, Jonas Mir, Yi-Li Cho, Marten Plambeck, Irina Treise, Albulena Toska, Susanne Heinzel, Matthias Schiemann, Dirk H Busch and 1 more

Abstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Design principles of the cytotoxic CD8Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Design principles of the cytotoxic CD8bioRxiv : the preprint server for biology · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Epigenetic Regulation of CD8European journal of immunology · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. LIM-domain-only 4 (LMO4) enhances CD8Signal transduction and targeted therapy · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lorenz KretschmerInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Michael FlossdorfInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Jonas MirInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.ORCID http://orcid.org/0000-0003-2067-6289
Yi-Li ChoInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Marten PlambeckInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Irina TreiseInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Albulena ToskaInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.ORCID http://orcid.org/0000-0002-4519-9493
Susanne HeinzelDivision of Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID http://orcid.org/0000-0001-9524-2835
Matthias SchiemannInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany.
Dirk H BuschInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany. dirk.busch@tum.de.ORCID http://orcid.org/0000-0001-8713-093X
Veit R BuchholzInstitute for Medical Microbiology, Immunology and Hygiene, Technische Universität München (TUM), Munich, Germany. veit.buchholz@tum.de.ORCID http://orcid.org/0000-0003-0441-3913

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While antigen-primed T cells proliferate at speeds close to the physiologic maximum of mammalian cells, T cell memory is maintained in the absence of antigen by rare cell divisions. The transition between these distinct proliferative programs has been difficult to resolve via population-based analyses. Here, we computationally reconstruct the proliferative history of single CD8

Indexed as

Cell DifferentiationCell DivisionImmunologic MemoryAnimalsCD8-Positive T-LymphocytesCell CycleFemaleInterleukin-2MiceMice, Inbred C57BLT-Lymphocyte SubsetsInterleukin-2

Identifiers

PMID31913278
PMCPMC6949285

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.