Evidence map›Paper›PMID 31913123›Full record

ArticleeLife2020

Presynaptic developmental plasticity allows robust sparse wiring of the

Najia A Elkahlah, Jackson A Rogow, Maria Ahmed, E Josephine Clowney

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cell cycle re-entry in the agingbioRxiv : the preprint server for biology · 2024
    Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Hacking brain development to test models of sensory coding.bioRxiv : the preprint server for biology · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. ClassifyingiScience · 2022
    Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Najia A Elkahlah *Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, United States.ORCID 0000-0002-9657-1777
Jackson A Rogow *Laboratory of Neurophysiology and Behavior, The Rockefeller University, New York, United States.ORCID 0000-0001-5060-6770
Maria AhmedDepartment of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, United States.ORCID 0000-0003-0054-3315
E Josephine ClowneyDepartment of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, United States.ORCID 0000-0002-9150-9464
University of Michigan · USRockefeller University · US

Funding

Generation and manipulation of combinatorial connectivity in olfactory perceptionR01DC018032 · NIDCD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eleanor Josephine Clowney · 2020 to 2026
$2.7M
Alfred P. Sloan Foundation Research Fellow in NeuroscienceHelen Hay Whitney Foundation Simons FellowNIDCD NIH HHS R01 DC018032Rita Allen Foundation Milton Cassel ScholarUniversity of Michigan Neuroscience Scholar AwardUniversity of Michigan Startup Funds
6 · The paper itself

Abstract

In order to represent complex stimuli, principle neurons of associative learning regions receive combinatorial sensory inputs. Density of combinatorial innervation is theorized to determine the number of distinct stimuli that can be represented and distinguished from one another, with sparse innervation thought to optimize the complexity of representations in networks of limited size. How the convergence of combinatorial inputs to principle neurons of associative brain regions is established during development is unknown. Here, we explore the developmental patterning of sparse olfactory inputs to Kenyon cells of the

Indexed as

AnimalsCell CountCell ProliferationDendritesDrosophila melanogasterMushroom BodiesOdorantsOlfactory PathwaysOlfactory Receptor NeuronsSmellSynapsescombinatorialdevelopmental biologyD. melanogastermushroom bodyneurosciencenon-deterministicolfactionsensory perceptionsparse coding

Identifiers

PMID31913123
PMCPMC7028369
OpenAlexW2999915254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.