Evidence map›Paper›PMID 31913053›Full record

ArticleJournal of psychopharmacology (Oxford, England)2020

Association of regulatory variants of dopamine β-hydroxylase with cognition and tardive dyskinesia in schizophrenia subjects.

Toyanji J Punchaichira, Anirban Mukhopadhyay, Prachi Kukshal, Triptish Bhatia, Smita N Deshpande, B K Thelma

Open access · greenAbstract read
In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Toyanji J PunchaichiraDepartment of Genetics, University of Delhi South Campus, New Delhi, India.
Anirban MukhopadhyayDepartment of Genetics, University of Delhi South Campus, New Delhi, India.
Prachi KukshalDepartment of Genetics, University of Delhi South Campus, New Delhi, India.
Triptish BhatiaDepartment of Psychiatry, Postgraduate Institute of Medical Education and Research-Dr. Ram Manohar Lohia Hospital, New Delhi, India.
Smita N DeshpandeDepartment of Psychiatry, Postgraduate Institute of Medical Education and Research-Dr. Ram Manohar Lohia Hospital, New Delhi, India.
B K ThelmaDepartment of Genetics, University of Delhi South Campus, New Delhi, India.ORCID 0000-0002-2154-5443
University of Delhi · INAtal Bihari Vajpayee Institute of Medical Sciences and Dr. Ram Manohar Lohia Hospital · IN

Funding

Integrated Networks of Scholars in Global Health Research Training (INSIGHT) Program D43TW012274 · FIC · UNIVERSITY OF MARYLAND BALTIMORE · PI Olakunle Alonge, Jessica Griffin Burke · 2022 to 2026
$6.5M
Psychiatric research infrastructure for intervention and implementation in India – TEAMSD43TW009114 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Smita N Deshpande, Mary Elizabeth Hawk · 2014 to 2026
$3.2M
Genetic Susceptibility in SchizophreniaR01MH056242 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 2002 to 2007
$2.9M
Training Program for Psychiatric Genetics in IndiaD43TW006167 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NIMGAONKAR, VISHWAJIT LAXMIKANT · 2002 to 2006
$1.7M
Tri National Training Program in Psychiatric GeneticsD43TW008302 · FIC · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MANSOUR, HADER A., NIMGAONKAR, VISHWAJIT LAXMIKANT · 2009 to 2013
$542k
FIC NIH HHS D43 TW006167FIC NIH HHS D43 TW008302FIC NIH HHS D43 TW009114FIC NIH HHS D43 TW012274NIMH NIH HHS R01 MH056242
6 · The paper itself

Abstract

backgroundDopamine-β-hydroxylase (DBH, EC 1.14.17.1), which converts dopamine to norepinephrine, is a candidate gene in neuropsychiatric diseases.

aimTo assess the effect of regulatory variants in

methodsWe tested association of functional variants 19bp

resultsA modest haplotypic (

conclusionsWith modest genotype-phenotype correlations available for

Indexed as

CognitionAdultCase-Control StudiesDopamine beta-HydroxylaseEndophenotypesFemaleGenetic Association StudiesHaplotypesHumansMalePolymorphism, GeneticSchizophreniaSchizophrenic PsychologyTardive DyskinesiaYoung AdultDopamine beta-Hydroxylase19bp Ins/Del (rs141116007)cognitionDopamine-β-hydroxylasedual luciferase reporter assaygenetic interactionregulatory variantsrs1611115rs1989787schizophreniatardive dyskinesia

Identifiers

PMID31913053
PMCPMC7150076
OpenAlexW2999245314

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.