ArticlePediatric pulmonology2020
Pediatric obesity-related asthma: A prototype of pediatric severe non-T2 asthma.
Article in Pediatric pulmonology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Comparative response to pharmacological management of asthma in overweight/obese childrenEuropean respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Genetic research on childhood obesity and asthma: exploring genetic risk factors and biological mechanisms.Pediatric research · 2026Review
- The Impact of Obesity on Airway Inflammation, Lung Function and Biologic Treatment in Asthma: A Narrative Review.Journal of inflammation research · 2026Review
- Metformin use is associated with reduced systemic steroid courses among pediatric asthma patients with diabetes or elevated blood glucose levels.Respiratory medicine · 2025 · on this mapObservational
- Immunocyte phenotypes and childhood disease susceptibility: insights from bidirectional Mendelian randomization and implications for immunomodulatory therapies.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Impact of natal and childhood metabolic markers on childhood asthma burden - a nationwide cohort study.Respiratory research · 2025Article
- Identifying the Genetic Ancestry of the Pediatric Obesity-Related Asthma Variant (rs6494395) at Rps27l.Pediatric pulmonology · 2025Article
- Metabolic syndrome and pulmonary dysfunction in asthmatic children during the COVID-19 pandemic.Clinical and experimental pediatrics · 2024Article
- Metformin use is associated with decreased asthma exacerbations in adolescents and young adults.Pediatric pulmonology · 2024Article
- Obesity and Selected Allergic and Immunological Diseases-Etiopathogenesis, Course and Management.Nutrients · 2023Review
- Chronic jet lag alters gut microbiome and mycobiome and promotes the progression of MAFLD in HFHFD-fed mice.Frontiers in microbiology · 2023Article
- T-helper cells and their cytokines in pathogenesis and treatment of asthma.Frontiers in immunology · 2023Review
- Obesity-related asthma in children and adolescents.The Lancet. Child & adolescent health · 2022Review
- Paediatric asthma and non-allergic comorbidities: A review of current risk and proposed mechanisms.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Review
- Paucigranulocytic Asthma: Potential Pathogenetic Mechanisms, Clinical Features and Therapeutic Management.Journal of personalized medicine · 2022Review
- Th1 cytokines synergize to change gene expression and promote corticosteroid insensitivity in pediatric airway smooth muscle.Respiratory research · 2022Article
- High Insulin in Early Childhood Is Associated with Subsequent Asthma Risk Independent of Body Mass Index.The journal of allergy and clinical immunology. In practice · 2022Article
- An Overview of the Obese-Asthma Phenotype in Children.International journal of environmental research and public health · 2022Review
- Obesity-associated asthma in childhood.Allergologie select · 2020Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Childhood obesity contributes to many diseases, including asthma. There is literature to suggest that asthma developing as a consequence of obesity has a nonallergic or non-T2 phenotype. In this review, obesity-related asthma is utilized as a prototype of non-T2 asthma in children to discuss several nonallergic mechanisms that underlie childhood asthma. Obesity-related asthma is associated with systemic T helper (Th)1 polarization occurring with monocyte activation. These immune responses are mediated by insulin resistance and dyslipidemia, metabolic abnormalities associated with obesity, that are themselves associated with pulmonary function deficits in obese asthmatics. As in other multifactorial diseases, there is both a genetic and an environmental contribution to pediatric obesity-related asthma. In addition to genetic susceptibility, differential DNA methylation is associated with non-T2 immune responses in pediatric obesity-related asthma. Initial investigations into the biology of non-T2 immune responses have identified the upregulation of genes in the CDC42 pathway. CDC42 is a RhoGTPase that plays a key role in Th cell physiology, including preferential naïve Th cell differentiation to Th1 cells, and cytokine production and exocytosis. Although these novel pathways are promising findings to direct targeted therapy development for obesity-related asthma to address the disease burden, there is evidence to suggest that dietary interventions, including diet modification, rather than caloric restriction alone, decrease disease burden. Adoption of a diet rich in micronutrients, including carotenoids and 25-OH cholecalciferol, a vitamin D metabolite, may be beneficial since these are positively correlated with pulmonary function indices, while being protective against metabolic abnormalities associated with the obese asthma phenotype.
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Registered trials
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