ArticleJournal of clinical laboratory analysis2020
Cytokine characteristic of cerebrospinal fluid from children with enteroviral meningitis compared to bacterial meningitis.
Article in Journal of clinical laboratory analysis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Differential cytokine signature profiles in neonates, infants, and children with enterovirus meningitis.Journal of virology · 2026Observational
- Cerebrospinal fluid cytokines and chemokines exhibit distinct profiles in bacterial meningitis and viral meningitis.Experimental and therapeutic medicine · 2023Article
- Expression of Th1/2/17 Cytokines in CML with or without Pulmonary Bacterial and Fungal Coinfection.Journal of oncology · 2023Review
- Increased peripheral inflammatory responses in myelin oligodendrocyte glycoprotein associated disease and aquaporin-4 antibody positive neuromyelitis optica spectrum disorder.Frontiers in immunology · 2022Article
- Increased Cytokine Levels Assist in the Diagnosis of Respiratory Bacterial Infections or Concurrent Bacteremia in Patients With Non-Hodgkin's Lymphoma.Frontiers in cellular and infection microbiology · 2022Article
- Longitudinal in vivo imaging of acute neuropathology in a monkey model of Ebola virus infection.Nature communications · 2021Article
- Cytokine Expression of Lung Bacterial Infection in Newly Diagnosed Adult Hematological Malignancies.Frontiers in immunology · 2021Article
- Cytokine characteristic of cerebrospinal fluid from children with enteroviral meningitis compared to bacterial meningitis.Journal of clinical laboratory analysis · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEnteroviruses are the most common etiological agent for viral encephalitis, but it is uncertain whether the cytokines have the ability to differentiate enteroviral meningitis (EVM) from bacterial meningitis (BM).
methodsA retrospective study was performed at the Children's Hospital, Zhejiang University School of Medicine from August 2016 and August 2019. CSF and/or blood specimens were collected for microbiological culture, viruses, and cytokine detection.
resultsForty-three patients were confirmed with meningitis, 27 patients with EVM, and 16 with BM. Children with EVM were older compared with BM and Control group (P < .001). The most common presenting symptom in children with EVM was fever (96.3%) followed by headache (88.9%) and vomiting (66.7%). The occurrence of seizure was lower in both EVM and BM groups (P < .001). Serum IL-6 and serum IL-10 were lower in EVM group than BM (P = .02) and control group (IL-6, P = .01; IL-10, P < .001). IL-6, IL-10, and IFN-γ levels showed obviously increase in CSF (P < .001, respectively) in EVM group, while only IL-6 increased in CSF (P < .001) in BM group. CSF concentrations of cytokines IL-6, IL-10, TNF, and IFN-γ in children with EVM and BM were both higher than Control group (P < .001). But compared EVM group to BM group, CSF IL-2 (P = .13), IL-6 (P = .37), IL-10 (P = .98), TNF (P = .54), and IFN-γ (P = .53) showed no difference between two groups.
conclusionsCSF cytokines elevated in both virus and bacterial meningitis, while serum elevation only occurred in bacterial infection. Still, we could not distinguish enteroviral meningitis from bacterial meningitis with the parameters of CSF cytokines IL-2, IL-6, IL-10, TNF, and IFN-γ.
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