Evidence map›Paper›PMID 31912782›Full record

ArticleAnnals of oncology : official journal of the European Society for Medical Oncology2020

Measures of body fatness and height in early and mid-to-late adulthood and prostate cancer: risk and mortality in The Pooling Project of Prospective Studies of Diet and Cancer.

J M Genkinger, K Wu, M Wang, D Albanes, A Black, P A van den Brandt, K A Burke, M B Cook, S M Gapstur, G G Giles and 20 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of oncology : official journal of the European Society for Medical Oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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  5. Differential Biopsy Patterns Influence Associations between Multivitamin Use and Prostate Cancer Risk in the Selenium and Vitamin E Cancer Prevention Trial.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

30 authors at 15 institutions in 6 countries.

J M GenkingerDepartment of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, USA; Cancer Epidemiology Program, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, USA. Electronic address: jg3081@columbia.edu.
K WuDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, USA.
M WangDepartment of Epidemiology, Harvard TH Chan School of Public Health, Boston, USA; Department of Biostatistics, Harvard TH Chan School of Public Health, Boston, USA; Department of Medicine, Harvard Medical School, Boston, USA.
D AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, USA.
A BlackDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, USA.
P A van den BrandtDepartment of Epidemiology, GROW-School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands.
K A BurkeDepartment of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, USA.
M B CookDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, USA.
S M GapsturBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, USA.
G G GilesCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
E GiovannucciDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, USA; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, USA; Department of Medicine, Harvard Medical School, Boston, USA.
G G GoodmanDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA.
P J GoodmanSWOG Statistical Center, Seattle, USA.
N HåkanssonDivision of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
T J KeyCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
S MännistöDepartment of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland.
L Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, USA.
L M LiaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, USA.
R J MacInnisCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Australia; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia.
M L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA.
E A PlatzDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
N SawadaEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
J M SchenkDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, USA.
V L StevensBehavioral and Epidemiology Research Group, American Cancer Society, Atlanta, USA.
R C TravisCancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
S TsuganeEpidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
K VisvanathanDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA.
L R WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, USA.
A WolkDivision of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
S A Smith-WarnerDepartment of Nutrition, Harvard TH Chan School of Public Health, Boston, USA; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, USA.
Harvard University · USFred Hutch Cancer Center · USAmerican Cancer Society · USCancer Council Victoria · AUColumbia University Irving Medical Center · USJohns Hopkins University · USKarolinska Institutet · SEUnited States Department of Health and Human Services · USUniversity of Oxford · GBCancer Center of Hawaii · USDivision of Cancer Epidemiology and GeneticsFinnish Institute for Health and Welfare · FIMaastricht University · NLNational Cancer Institute · USUniversity of Hawaii System · US

Funding

SWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2M
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
Validity of Diet and Activity Measures in WomenP01CA055075 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI RIMM, ERIC B · 1991 to 2009
$41.8M
PCPT and SELECT Cohorts: Core Infrastructure Support for Cancer ResearchU01CA182883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TANGEN, CATHERINE M., THOMPSON, IAN M. · 2019 to 2023
$5.4M
Nutritional Epidemiology of Cancer Education and Career Development ProgramR25CA098566 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI STAMPFER, MEIR · 2003 to 2013
$4.5M
Cancer Research UK 19170Cancer Research UK 29017NCI NIH HHS P01 CA055075NCI NIH HHS R25 CA098566NCI NIH HHS U01 CA182883NCI NIH HHS U10 CA037429NCI NIH HHS UG1 CA189974
6 · The paper itself

Abstract

backgroundAdvanced prostate cancer etiology is poorly understood. Few studies have examined associations of anthropometric factors (e.g. early adulthood obesity) with advanced prostate cancer risk. PATIENTS AND

methodsWe carried out pooled analyses to examine associations between body fatness, height, and prostate cancer risk. Among 830 772 men, 51 734 incident prostate cancer cases were identified, including 4762 advanced (T4/N1/M1 or prostate cancer deaths) cases, 2915 advanced restricted (same as advanced, but excluding localized cancers that resulted in death) cases, 9489 high-grade cases, and 3027 prostate cancer deaths. Cox proportional hazards models were used to calculate study-specific hazard ratios (HR) and 95% confidence intervals (CI); results were pooled using random effects models.

resultsNo statistically significant associations were observed for body mass index (BMI) in early adulthood for advanced, advanced restricted, and high-grade prostate cancer, and prostate cancer mortality. Positive associations were shown for BMI at baseline with advanced prostate cancer (HR = 1.30, 95% CI = 0.95-1.78) and prostate cancer mortality (HR = 1.52, 95% CI = 1.12-2.07) comparing BMI ≥35.0 kg/m

conclusionOur findings suggest that height and total and central adiposity in mid-to-later adulthood, but not early adulthood adiposity, are associated with risk of advanced forms of prostate cancer. Thus, maintenance of healthy weight may help prevent advanced prostate cancer.

Indexed as

Prostatic NeoplasmsAdultBody HeightBody Mass IndexDietHumansMaleProportional Hazards ModelsProspective StudiesRisk FactorsWaist CircumferenceBMIbody fatnessheightpooled analysisprostate cancerwaist

Identifiers

PMID31912782
PMCPMC8195110
OpenAlexW2998876387

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.